Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123

Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123

Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression. Here, we used alpharetroviral vectors to modify NK-92 cell...

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Bibliographic Details
Main Authors: Michael A. Morgan, Arnold Kloos, Daniela Lenz, Nadine Kattre, Juliette Nowak, Marco Bentele, Maximilian Keisker, Julia Dahlke, Katharina Zimmermann, Martin Sauer, Michael Heuser, Axel Schambach
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
alpharetroviral vector
acute myeloid leukemia
chimeric antigen receptor
CD123
interleukin 3 receptor subunit alpha
patient-derived xenograft
Online Access:https://www.mdpi.com/1999-4915/13/7/1365

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