H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering...
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Series: | Neoplasia: An International Journal for Oncology Research |
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doaj-484881027ba04240bbe907377d7af3fd2020-11-25T01:04:45ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862017-03-01193226236H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer CellsShanwen Chen0Dingfang Bu1Yuanyuan Ma2Jing Zhu3Guowei Chen4Lie Sun5Shuai Zuo6Tengyu Li7Yisheng Pan8Xin Wang9Yucun Liu10Pengyuan Wang11Division of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaCentral Laboratory, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaAnimal Experiment Center, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of ChinaDivision of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of China; Address all correspondence to: Yucun Liu or Pengyuan Wang, Division of General Surgery, Peking University First Hospital, Peking University, 8 Xi Shiku Street, Beijing, 100034, People's Republic of China.Division of General Surgery, Peking University First Hospital, Peking University, 8 Xi ShiKu Street, Beijing 100034, People's Republic of China; Address all correspondence to: Yucun Liu or Pengyuan Wang, Division of General Surgery, Peking University First Hospital, Peking University, 8 Xi Shiku Street, Beijing, 100034, People's Republic of China.The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of VDR signaling in the colon epithelium both physiologically and pathologically, the correlation between H19 and VDR signaling may have an important role in the development of colon cancer. In this study, the correlation between H19 and vitamin D receptor (VDR) signaling and the underlying mechanisms in colon cancer were investigated both in vitro and in vivo. The results suggested that VDR signaling was able to inhibit the expression of H19 through regulating C-Myc/Mad-1 network. H19, on the other hand, was able to inhibit the expression of VDR through micro RNA 675-5p (miR-675-5p). Furthermore, H19 overexpression induced resistance to the treatment with 1,25(OH)2D3 both in vitro and in vivo. Together, these results suggested that H19 overexpression might be one of the mechanisms underlying the development of resistance to the treatment with 1,25(OH)2D3 in the advanced stage of colon cancer.http://www.sciencedirect.com/science/article/pii/S1476558616301816 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shanwen Chen Dingfang Bu Yuanyuan Ma Jing Zhu Guowei Chen Lie Sun Shuai Zuo Tengyu Li Yisheng Pan Xin Wang Yucun Liu Pengyuan Wang |
spellingShingle |
Shanwen Chen Dingfang Bu Yuanyuan Ma Jing Zhu Guowei Chen Lie Sun Shuai Zuo Tengyu Li Yisheng Pan Xin Wang Yucun Liu Pengyuan Wang H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells Neoplasia: An International Journal for Oncology Research |
author_facet |
Shanwen Chen Dingfang Bu Yuanyuan Ma Jing Zhu Guowei Chen Lie Sun Shuai Zuo Tengyu Li Yisheng Pan Xin Wang Yucun Liu Pengyuan Wang |
author_sort |
Shanwen Chen |
title |
H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells |
title_short |
H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells |
title_full |
H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells |
title_fullStr |
H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells |
title_full_unstemmed |
H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells |
title_sort |
h19 overexpression induces resistance to 1,25(oh)2d3 by targeting vdr through mir-675-5p in colon cancer cells |
publisher |
Elsevier |
series |
Neoplasia: An International Journal for Oncology Research |
issn |
1476-5586 |
publishDate |
2017-03-01 |
description |
The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of VDR signaling in the colon epithelium both physiologically and pathologically, the correlation between H19 and VDR signaling may have an important role in the development of colon cancer. In this study, the correlation between H19 and vitamin D receptor (VDR) signaling and the underlying mechanisms in colon cancer were investigated both in vitro and in vivo. The results suggested that VDR signaling was able to inhibit the expression of H19 through regulating C-Myc/Mad-1 network. H19, on the other hand, was able to inhibit the expression of VDR through micro RNA 675-5p (miR-675-5p). Furthermore, H19 overexpression induced resistance to the treatment with 1,25(OH)2D3 both in vitro and in vivo. Together, these results suggested that H19 overexpression might be one of the mechanisms underlying the development of resistance to the treatment with 1,25(OH)2D3 in the advanced stage of colon cancer. |
url |
http://www.sciencedirect.com/science/article/pii/S1476558616301816 |
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