Production of Knockout Mice using CRISPR/Cas9 in FVB Strain

Production of Knockout Mice using CRISPR/Cas9 in FVB Strain

KO mice provide an excellent tool to determine roles of specific genes in biomedical filed. Traditionally, knockout mice were generated by homologous recombination in embryonic stem cells. Recently, engineered nucleases, such as zinc finger nuclease, transcription activator-like effector nuclease an...

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Bibliographic Details
Main Authors: Hee Sook Bae, Soo Jin Lee, Ok Jae Koo
Format: Article
Language:English
Published: The Korean Society of Animal Reproduction and Biotechnology 2015-12-01
Series:Journal of Animal Reproduction and Biotechnology
Subjects:
crispr-cas9
knockout mice
fvb
Online Access:http://www.e-jarb.org/journal/view.html?uid=1499&vmd=Full

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