Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role...
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2020-11-01
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doaj-485ed477696b4ca5b71b769c0cdb63e92020-11-25T04:06:42ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-11-011110.3389/fphys.2020.595086595086Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular DevelopmentHong Zhang0Fengping Lin1Jiuhua Zhao2Jiuhua Zhao3Zhengchao Wang4Provincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, ChinaProvincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, ChinaProvincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, ChinaWest Anhui Health Vocational College, Lu’an, ChinaProvincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, ChinaIn mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology.https://www.frontiersin.org/articles/10.3389/fphys.2020.595086/fulltranscription factor FOXO3acell cycleapoptosisoxidative stressenergy metabolismfollicular development |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong Zhang Fengping Lin Jiuhua Zhao Jiuhua Zhao Zhengchao Wang |
spellingShingle |
Hong Zhang Fengping Lin Jiuhua Zhao Jiuhua Zhao Zhengchao Wang Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development Frontiers in Physiology transcription factor FOXO3a cell cycle apoptosis oxidative stress energy metabolism follicular development |
author_facet |
Hong Zhang Fengping Lin Jiuhua Zhao Jiuhua Zhao Zhengchao Wang |
author_sort |
Hong Zhang |
title |
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development |
title_short |
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development |
title_full |
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development |
title_fullStr |
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development |
title_full_unstemmed |
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development |
title_sort |
expression regulation and physiological role of transcription factor foxo3a during ovarian follicular development |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-11-01 |
description |
In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology. |
topic |
transcription factor FOXO3a cell cycle apoptosis oxidative stress energy metabolism follicular development |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2020.595086/full |
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