Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure
Background: <i>Taraxacum officinale (</i>TO<i>) </i>or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the poss...
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doaj-48646737969444f696a340f6de0fc86f2021-03-25T00:01:38ZengMDPI AGAntioxidants2076-39212021-03-011050450410.3390/antiox10040504Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver FailureIulia Olimpia Pfingstgraf0Marian Taulescu1Raluca Maria Pop2Remus Orăsan3Laurian Vlase4Ana Uifalean5Doina Todea6Teodora Alexescu7Corina Toma8Alina Elena Pârvu9Department of Pathophysiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Physiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pathophysiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pneumology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaDepartment of Pathophysiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, RomaniaBackground: <i>Taraxacum officinale (</i>TO<i>) </i>or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-galactosamine and lipopolysaccharide (D-Gal-LPS). Five groups (<i>n</i> = 5) of male Wistar rats (200–250 g) were used: ACLF, ACLF-silymarin (200 mg/kg b.w./day), three ACLF-TO administered in three doses (200 mg, 100 mg, 50 mg/kg b.w./day). Results: The in vivo results showed that treatment with TOERE administered in three chosen doses before ACLF induction reduced serum liver injury markers (AST, ALT, ALP, GGT, total bilirubin), renal tests (creatinine, urea), and oxidative stress tests (TOS, OSI, MDA, NO, 3NT). Histopathologically, TOERE diminished the level of liver tissue injury and 3NT immunoexpression. Conclusions: This paper indicated oxidative stress reduction as possible mechanisms for the hepatoprotective effect of TOERE in ACLF and provided evidence for the preventive treatment.https://www.mdpi.com/2076-3921/10/4/504acute on chronic liver failurehepatoprotectiveoxidative stress<i>Taraxacum officinale</i>3-nitrotyrosine |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iulia Olimpia Pfingstgraf Marian Taulescu Raluca Maria Pop Remus Orăsan Laurian Vlase Ana Uifalean Doina Todea Teodora Alexescu Corina Toma Alina Elena Pârvu |
spellingShingle |
Iulia Olimpia Pfingstgraf Marian Taulescu Raluca Maria Pop Remus Orăsan Laurian Vlase Ana Uifalean Doina Todea Teodora Alexescu Corina Toma Alina Elena Pârvu Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure Antioxidants acute on chronic liver failure hepatoprotective oxidative stress <i>Taraxacum officinale</i> 3-nitrotyrosine |
author_facet |
Iulia Olimpia Pfingstgraf Marian Taulescu Raluca Maria Pop Remus Orăsan Laurian Vlase Ana Uifalean Doina Todea Teodora Alexescu Corina Toma Alina Elena Pârvu |
author_sort |
Iulia Olimpia Pfingstgraf |
title |
Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure |
title_short |
Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure |
title_full |
Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure |
title_fullStr |
Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure |
title_full_unstemmed |
Protective Effects of <i>Taraxacum officinale</i> L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure |
title_sort |
protective effects of <i>taraxacum officinale</i> l. (dandelion) root extract in experimental acute on chronic liver failure |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2021-03-01 |
description |
Background: <i>Taraxacum officinale (</i>TO<i>) </i>or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-galactosamine and lipopolysaccharide (D-Gal-LPS). Five groups (<i>n</i> = 5) of male Wistar rats (200–250 g) were used: ACLF, ACLF-silymarin (200 mg/kg b.w./day), three ACLF-TO administered in three doses (200 mg, 100 mg, 50 mg/kg b.w./day). Results: The in vivo results showed that treatment with TOERE administered in three chosen doses before ACLF induction reduced serum liver injury markers (AST, ALT, ALP, GGT, total bilirubin), renal tests (creatinine, urea), and oxidative stress tests (TOS, OSI, MDA, NO, 3NT). Histopathologically, TOERE diminished the level of liver tissue injury and 3NT immunoexpression. Conclusions: This paper indicated oxidative stress reduction as possible mechanisms for the hepatoprotective effect of TOERE in ACLF and provided evidence for the preventive treatment. |
topic |
acute on chronic liver failure hepatoprotective oxidative stress <i>Taraxacum officinale</i> 3-nitrotyrosine |
url |
https://www.mdpi.com/2076-3921/10/4/504 |
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