Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis
Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown. Here, authors show that genetic and pharmacological modulation of actin polymerization disrupts nuclear pore integ...
Main Authors: | Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown, Antonia Ratti, John E. Landers, Claudia Fallini |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11837-y |
Similar Items
-
Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis.
by: Jee-Eun Kim, et al.
Published: (2017-01-01) -
Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis
by: Nadia eD'Ambrosi, et al.
Published: (2014-09-01) -
Amyotrophic lateral sclerosis
by: Leigh P Nigel, et al.
Published: (2009-02-01) -
Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis
by: Valentina Cappello, et al.
Published: (2017-10-01) -
Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
by: Deborah Ferrara, et al.
Published: (2018-08-01)