VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver....
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21715-1 |
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doaj-48717331846c4d5699d2e8a3c33c51922021-03-11T11:33:31ZengNature Publishing GroupNature Communications2041-17232021-02-0112111910.1038/s41467-021-21715-1VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolismYu-Hsuan Chen0Tzu-Yu Huang1Yu-Tung Lin2Shu-Yu Lin3Wen-Hsin Li4Hsiang-Jung Hsiao5Ruei-Liang Yan6Hong-Wen Tang7Zhao-Qing Shen8Guang-Chao Chen9Kuen-Phon Wu10Ting-Fen Tsai11Ruey-Hwa Chen12Institute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming UniversityInstitute of Biological Chemistry, Academia SinicaInstitute of Biological Chemistry, Academia SinicaDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming UniversityInstitute of Biological Chemistry, Academia SinicaAutophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver.https://doi.org/10.1038/s41467-021-21715-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen |
| spellingShingle |
Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism Nature Communications |
| author_facet |
Yu-Hsuan Chen Tzu-Yu Huang Yu-Tung Lin Shu-Yu Lin Wen-Hsin Li Hsiang-Jung Hsiao Ruei-Liang Yan Hong-Wen Tang Zhao-Qing Shen Guang-Chao Chen Kuen-Phon Wu Ting-Fen Tsai Ruey-Hwa Chen |
| author_sort |
Yu-Hsuan Chen |
| title |
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism |
| title_short |
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism |
| title_full |
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism |
| title_fullStr |
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism |
| title_full_unstemmed |
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism |
| title_sort |
vps34 k29/k48 branched ubiquitination governed by ube3c and trabid regulates autophagy, proteostasis and liver metabolism |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-02-01 |
| description |
Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has an important role in lipid metabolism in the liver. |
| url |
https://doi.org/10.1038/s41467-021-21715-1 |
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