Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of...

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Bibliographic Details
Main Authors: Christophe Rodriguez, Guillaume Gricourt, Melissa Ndebi, Vanessa Demontant, Lila Poiteau, Sonia Burrel, David Boutolleau, Paul-Louis Woerther, Vincent Calvez, Sebastian Stroer, Jean-Michel Pawlotsky
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2020-06-01
Series:Emerging Infectious Diseases
Subjects:
orthobunyavirus
shotgun metagenomics
encephalitis
viruses
Cristoli virus
France
Online Access:https://wwwnc.cdc.gov/eid/article/26/6/19-1431_article
Description
Summary:We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.
ISSN:1080-6040
1080-6059

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