Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of...

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Main Authors: Christophe Rodriguez, Guillaume Gricourt, Melissa Ndebi, Vanessa Demontant, Lila Poiteau, Sonia Burrel, David Boutolleau, Paul-Louis Woerther, Vincent Calvez, Sebastian Stroer, Jean-Michel Pawlotsky
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2020-06-01
Series:Emerging Infectious Diseases
Subjects:
orthobunyavirus
shotgun metagenomics
encephalitis
viruses
Cristoli virus
France
Online Access:https://wwwnc.cdc.gov/eid/article/26/6/19-1431_article
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spelling doaj-48717d0d492643d7838b0c736302168a2020-11-25T03:04:05ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592020-06-012661287129010.3201/eid2606.191431Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, FranceChristophe RodriguezGuillaume GricourtMelissa NdebiVanessa DemontantLila PoiteauSonia BurrelDavid BoutolleauPaul-Louis WoertherVincent CalvezSebastian StroerJean-Michel PawlotskyWe report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.https://wwwnc.cdc.gov/eid/article/26/6/19-1431_articleorthobunyavirusshotgun metagenomicsencephalitisvirusesCristoli virusFrance
collection DOAJ
language English
format Article
sources DOAJ
author Christophe Rodriguez
Guillaume Gricourt
Melissa Ndebi
Vanessa Demontant
Lila Poiteau
Sonia Burrel
David Boutolleau
Paul-Louis Woerther
Vincent Calvez
Sebastian Stroer
Jean-Michel Pawlotsky
spellingShingle Christophe Rodriguez
Guillaume Gricourt
Melissa Ndebi
Vanessa Demontant
Lila Poiteau
Sonia Burrel
David Boutolleau
Paul-Louis Woerther
Vincent Calvez
Sebastian Stroer
Jean-Michel Pawlotsky
Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
Emerging Infectious Diseases
orthobunyavirus
shotgun metagenomics
encephalitis
viruses
Cristoli virus
France
author_facet Christophe Rodriguez
Guillaume Gricourt
Melissa Ndebi
Vanessa Demontant
Lila Poiteau
Sonia Burrel
David Boutolleau
Paul-Louis Woerther
Vincent Calvez
Sebastian Stroer
Jean-Michel Pawlotsky
author_sort Christophe Rodriguez
title Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_short Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_full Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_fullStr Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_full_unstemmed Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_sort fatal encephalitis caused by cristoli virus, an emerging orthobunyavirus, france
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2020-06-01
description We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.
topic orthobunyavirus
shotgun metagenomics
encephalitis
viruses
Cristoli virus
France
url https://wwwnc.cdc.gov/eid/article/26/6/19-1431_article
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