Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors
Hidradenitis suppurativa is a common recurrent inflammatory skin disease. It is associated with multiple comorbidities whose temporal relationships are unknown due to long diagnostic delays. This study of otherwise healthy blood donors with self-reported symptoms of hidradenitis suppurativa investig...
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Society for Publication of Acta Dermato-Venereologica
2021-01-01
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3737
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doaj-4871c42b343d412dba5e43ac167666652021-01-20T11:34:17ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572021-01-011011adv0037610.2340/00015555-37375982Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood DonorsRune Kjærsgaard Andersen0Isabella Charlotte LoftKristoffer BurgdorfChristian ErikstrupOle B. PedersenGregor B.E. Jemec Department of Dermatology, Zealand University Hospital, DK-4000 Roskilde, Denmark. E-mail: ruka@regionsjaelland.dk. Hidradenitis suppurativa is a common recurrent inflammatory skin disease. It is associated with multiple comorbidities whose temporal relationships are unknown due to long diagnostic delays. This study of otherwise healthy blood donors with self-reported symptoms of hidradenitis suppurativa investigated the temporal relationships of comorbidities. A prospective survival analysis on a nationwide cohort of blood donors, using registry data on drug prescription, was used to calculate the hazard ratio of time until first prescription of medical treatment for the following hidradenitis suppurativa-related comorbidities: heart disease, diabetes, depression, thyroid disease and pain. Hidradenitis suppurativa status was determined by a validated questionnaire, and the survival analysis was adjusted for age, sex, body mass index, smoking status and having an International Classification of Diseases Version 10 (ICD-10) diagnosis of hidradenitis suppurativa. Of the participants, 1,012 reported hidradenitis suppurativa symptoms, and these symptoms increased the hazard ratio of antidepressants (1.73, 95% confidence interval 1.17–2.56, p ≈ 0.006) and analgesics (hazard ratio 1.24, 95% confidence interval 1.11–1.39, p < 0.001). Pain and depression are the first comorbidities to present in hidradenitis suppurativa pathogenesis. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3737 hidradenitis suppurativa survival analysis prescription comorbidity analgesia antidepressants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rune Kjærsgaard Andersen Isabella Charlotte Loft Kristoffer Burgdorf Christian Erikstrup Ole B. Pedersen Gregor B.E. Jemec |
spellingShingle |
Rune Kjærsgaard Andersen Isabella Charlotte Loft Kristoffer Burgdorf Christian Erikstrup Ole B. Pedersen Gregor B.E. Jemec Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors Acta Dermato-Venereologica hidradenitis suppurativa survival analysis prescription comorbidity analgesia antidepressants |
author_facet |
Rune Kjærsgaard Andersen Isabella Charlotte Loft Kristoffer Burgdorf Christian Erikstrup Ole B. Pedersen Gregor B.E. Jemec |
author_sort |
Rune Kjærsgaard Andersen |
title |
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors |
title_short |
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors |
title_full |
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors |
title_fullStr |
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors |
title_full_unstemmed |
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors |
title_sort |
risk of hidradenitis suppurativa comorbidities over time: a prospective cohort study of danish blood donors |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2021-01-01 |
description |
Hidradenitis suppurativa is a common recurrent inflammatory skin disease. It is associated with multiple comorbidities whose temporal relationships are unknown due to long diagnostic delays. This study of otherwise healthy blood donors with self-reported symptoms of hidradenitis suppurativa investigated the temporal relationships of comorbidities. A prospective survival analysis on a nationwide cohort of blood donors, using registry data on drug prescription, was used to calculate the hazard ratio of time until first prescription of medical treatment for the following hidradenitis suppurativa-related comorbidities: heart disease, diabetes, depression, thyroid disease and pain. Hidradenitis suppurativa status was determined by a validated questionnaire, and the survival analysis was adjusted for age, sex, body mass index, smoking status and having an International Classification of Diseases Version 10 (ICD-10) diagnosis of hidradenitis suppurativa. Of the participants, 1,012 reported hidradenitis suppurativa symptoms, and these symptoms increased the hazard ratio of antidepressants (1.73, 95% confidence interval 1.17–2.56, p ≈ 0.006) and analgesics (hazard ratio 1.24, 95% confidence interval 1.11–1.39, p < 0.001). Pain and depression are the first comorbidities to present in hidradenitis suppurativa pathogenesis. |
topic |
hidradenitis suppurativa survival analysis prescription comorbidity analgesia antidepressants |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3737
|
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