Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease.
The ability for a host to recognize infection is critical for virus clearance and often begins with induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to the pathophysiology of infection, although the mechanism for this is unclear. The NLRP3-inflammasome has be...
Main Authors: | Julie L McAuley, Michelle D Tate, Charley J MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E Brown, Ashley Mansell |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23737748/pdf/?tool=EBI |
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