Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy
The aim of the study is to assess choroidal thickness (CT) and choroidal volume (CV) in 90 type 1 diabetes mellitus (DM1) patients with no diabetic retinopathy (DR) and 60 control eyes using spectral domain optical coherence tomography (SD-OCT) and swept source (SS)-OCT in the areas of the Early Tre...
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doaj-48728fdb97124cea8b05886059b9018d2020-11-25T02:39:03ZengMDPI AGDiagnostics2075-44182020-04-011023523510.3390/diagnostics10040235Choroidal Changes of Long-Term Type 1 Diabetic Patients without RetinopathyElvira Orduna-Hospital0Lorena Perdices1Ana Sanchez-Cano2Javier Acha3Nicolás Cuenca4Isabel Pinilla5Research in Retina, Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, SpainResearch in Retina, Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, SpainResearch in Retina, Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, SpainResearch in Retina, Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, SpainDepartment of Physiology, Genetics and Microbiology, University of Alicante, 03690 Alicante, SpainResearch in Retina, Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, SpainThe aim of the study is to assess choroidal thickness (CT) and choroidal volume (CV) in 90 type 1 diabetes mellitus (DM1) patients with no diabetic retinopathy (DR) and 60 control eyes using spectral domain optical coherence tomography (SD-OCT) and swept source (SS)-OCT in the areas of the Early Treatment Diabetic Retinopathy Study (ETDRS). Mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control groups, respectively. Significant differences were obtained between both groups with Spectralis SD-OCT in all ETDRS areas and in the total CV, excluding the temporal perifoveal one. With Triton SS-OCT, statistically significant differences were obtained in the subfoveal CT and in the vertical areas. CT showed the same tendency with both OCTs, with greater CT and CV in the DM1 group than the mean values of the control group. To assess the influence of DM1 evolution in the CT modifications, DM1 patients were divided into Group 1, with less than 24 years of diagnosis, and Group 2, with ≥24 years of DM1 evolution. Using both OCTs, seven of the nine ETDRS areas and the CV had lower values in Group 2. CT and CV measured by OCT were higher in DM1 without DR. There is a choroidal thinning related to disease evolution in DM1. In patients with DM evolution greater than 24 years, the CT is statistically lower than in patients with less evolution of the disease.https://www.mdpi.com/2075-4418/10/4/235diabetic retinopathychoroidal thicknesschoroidal volumespectral domain optical coherence tomography (SD-OCT)swept source optical coherence tomography (SS-OCT)type 1 diabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elvira Orduna-Hospital Lorena Perdices Ana Sanchez-Cano Javier Acha Nicolás Cuenca Isabel Pinilla |
spellingShingle |
Elvira Orduna-Hospital Lorena Perdices Ana Sanchez-Cano Javier Acha Nicolás Cuenca Isabel Pinilla Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy Diagnostics diabetic retinopathy choroidal thickness choroidal volume spectral domain optical coherence tomography (SD-OCT) swept source optical coherence tomography (SS-OCT) type 1 diabetes mellitus |
author_facet |
Elvira Orduna-Hospital Lorena Perdices Ana Sanchez-Cano Javier Acha Nicolás Cuenca Isabel Pinilla |
author_sort |
Elvira Orduna-Hospital |
title |
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy |
title_short |
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy |
title_full |
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy |
title_fullStr |
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy |
title_full_unstemmed |
Choroidal Changes of Long-Term Type 1 Diabetic Patients without Retinopathy |
title_sort |
choroidal changes of long-term type 1 diabetic patients without retinopathy |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-04-01 |
description |
The aim of the study is to assess choroidal thickness (CT) and choroidal volume (CV) in 90 type 1 diabetes mellitus (DM1) patients with no diabetic retinopathy (DR) and 60 control eyes using spectral domain optical coherence tomography (SD-OCT) and swept source (SS)-OCT in the areas of the Early Treatment Diabetic Retinopathy Study (ETDRS). Mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control groups, respectively. Significant differences were obtained between both groups with Spectralis SD-OCT in all ETDRS areas and in the total CV, excluding the temporal perifoveal one. With Triton SS-OCT, statistically significant differences were obtained in the subfoveal CT and in the vertical areas. CT showed the same tendency with both OCTs, with greater CT and CV in the DM1 group than the mean values of the control group. To assess the influence of DM1 evolution in the CT modifications, DM1 patients were divided into Group 1, with less than 24 years of diagnosis, and Group 2, with ≥24 years of DM1 evolution. Using both OCTs, seven of the nine ETDRS areas and the CV had lower values in Group 2. CT and CV measured by OCT were higher in DM1 without DR. There is a choroidal thinning related to disease evolution in DM1. In patients with DM evolution greater than 24 years, the CT is statistically lower than in patients with less evolution of the disease. |
topic |
diabetic retinopathy choroidal thickness choroidal volume spectral domain optical coherence tomography (SD-OCT) swept source optical coherence tomography (SS-OCT) type 1 diabetes mellitus |
url |
https://www.mdpi.com/2075-4418/10/4/235 |
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