Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity

One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the therapeutic efficacy for VH results in limited suc...

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Main Authors:	Adnan Hassan Tahir, Jia-Jia Li, Yong Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Neuroscience
Subjects:	visceral hypersensitivity electro-acupuncture analgesia peripheral mechanism spinal cord neurological chemicals
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2021.696843/full

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spelling	doaj-48733993e2e149d7b3c9b9c406bc618f2021-09-29T06:06:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-09-011510.3389/fnins.2021.696843696843Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral HypersensitivityAdnan Hassan Tahir0Adnan Hassan Tahir1Jia-Jia Li2Jia-Jia Li3Yong Tang4Yong Tang5School of Acupuncture and Tuina and International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, ChinaSchool of Acupuncture and Tuina and International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, ChinaSchool of Acupuncture and Tuina and International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, ChinaOne of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the therapeutic efficacy for VH results in limited success. A popular second therapy that is being approved for the induction of analgesia and attenuates VH with fewer side effects includes electro-acupuncture (EA). Different peripheral and spinal neurological chemicals, including neurotransmitters, neuropeptides, and cytokines, and different signaling pathways were associated with EA treatment in VH. Despite the higher acceptance of EA, the underlying mechanism still needs to be further explored. In this paper, we review the available literature to find the peripheral and spinal mechanisms involved in EA to relieve VH.https://www.frontiersin.org/articles/10.3389/fnins.2021.696843/fullvisceral hypersensitivityelectro-acupuncture analgesiaperipheral mechanismspinal cordneurological chemicals
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Adnan Hassan Tahir Adnan Hassan Tahir Jia-Jia Li Jia-Jia Li Yong Tang Yong Tang
spellingShingle	Adnan Hassan Tahir Adnan Hassan Tahir Jia-Jia Li Jia-Jia Li Yong Tang Yong Tang Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity Frontiers in Neuroscience visceral hypersensitivity electro-acupuncture analgesia peripheral mechanism spinal cord neurological chemicals
author_facet	Adnan Hassan Tahir Adnan Hassan Tahir Jia-Jia Li Jia-Jia Li Yong Tang Yong Tang
author_sort	Adnan Hassan Tahir
title	Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
title_short	Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
title_full	Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
title_fullStr	Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
title_full_unstemmed	Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
title_sort	peripheral and spinal mechanisms involved in electro-acupuncture therapy for visceral hypersensitivity
publisher	Frontiers Media S.A.
series	Frontiers in Neuroscience
issn	1662-453X
publishDate	2021-09-01
description	One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the therapeutic efficacy for VH results in limited success. A popular second therapy that is being approved for the induction of analgesia and attenuates VH with fewer side effects includes electro-acupuncture (EA). Different peripheral and spinal neurological chemicals, including neurotransmitters, neuropeptides, and cytokines, and different signaling pathways were associated with EA treatment in VH. Despite the higher acceptance of EA, the underlying mechanism still needs to be further explored. In this paper, we review the available literature to find the peripheral and spinal mechanisms involved in EA to relieve VH.
topic	visceral hypersensitivity electro-acupuncture analgesia peripheral mechanism spinal cord neurological chemicals
url	https://www.frontiersin.org/articles/10.3389/fnins.2021.696843/full
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Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity

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