Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms
Sporadic Alzheimer's disease is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted however the details of this disease remain largely...
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doaj-48736268710b4a28aa64dbb30951a2f12020-11-24T23:15:27ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-07-01910.3389/fnins.2015.00245145619Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanismsDarryl Christopher Gidyk0Scott Harrison Deibel1Nancy S Hong2Robert J McDonald3University of LethbridgeUniversity of LethbridgeUniversity of LethbridgeUniversity of LethbridgeSporadic Alzheimer's disease is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted however the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be ethically studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00245/fullAlzheimer DiseaseCognitionDementiaHippocampusMemoryneurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Darryl Christopher Gidyk Scott Harrison Deibel Nancy S Hong Robert J McDonald |
spellingShingle |
Darryl Christopher Gidyk Scott Harrison Deibel Nancy S Hong Robert J McDonald Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms Frontiers in Neuroscience Alzheimer Disease Cognition Dementia Hippocampus Memory neurodegeneration |
author_facet |
Darryl Christopher Gidyk Scott Harrison Deibel Nancy S Hong Robert J McDonald |
author_sort |
Darryl Christopher Gidyk |
title |
Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
title_short |
Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
title_full |
Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
title_fullStr |
Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
title_full_unstemmed |
Barriers to developing a valid rodent model of Alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
title_sort |
barriers to developing a valid rodent model of alzheimer's disease: from behavioural analysis to etiologicalmechanisms |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2015-07-01 |
description |
Sporadic Alzheimer's disease is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted however the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be ethically studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa. |
topic |
Alzheimer Disease Cognition Dementia Hippocampus Memory neurodegeneration |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00245/full |
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1725591073092272128 |