Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Obesity Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances via MAPK Pathway Activation in Intervertebral Disk Degeneration

Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, by influencing levels of free fatty acids which could impair cell metabolism. This study aims to establish metabolic factors in obesity-related IDD independent of mechanical loading. In clinical study, we retrospecti...

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Bibliographic Details
Main Authors: Xuyang Zhang, Jian Chen, Bao Huang, Jiasheng Wang, Zhi Shan, Junhui Liu, Yilei Chen, Shengyun Li, Shunwu Fan, Fengdong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
obesity
apoptosis
extracellular matrix
MAPK pathway
intervertebral disk degeneration
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01284/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01284/full

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