Merkel cell polyomavirus detected in head and neck carcinomas from Chile
Abstract Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human...
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doaj-4883958900984e07aedd160d1ce947a62021-01-31T12:16:20ZengBMCInfectious Agents and Cancer1750-93782020-01-011511510.1186/s13027-020-0276-zMerkel cell polyomavirus detected in head and neck carcinomas from ChileJuan P. Muñoz0Rancés Blanco1Julio C. Osorio2Carolina Oliva3María José Diaz4Diego Carrillo-Beltrán5Rebeca Aguayo6Andrés Castillo7Julio C. Tapia8Gloria M. Calaf9Aldo Gaggero10Francisco Aguayo11Instituto de Alta Investigación (IAI), Universidad de TarapacaPrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChilePrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChilePrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChilePrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChilePrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChileCentro de Salud Familiar “El Roble”, Municipalidad de La PintanaDepartment of Biology, Faculty of Natural and Exact Sciences at Universidad del ValleDepartamento de Oncología Básico Clínica, Faculty of Medicine, University of ChileInstituto de Alta Investigación (IAI), Universidad de TarapacaPrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Faculty of Medicine, Universidad de ChileInstituto de Alta Investigación (IAI), Universidad de TarapacaAbstract Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects. Methods One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed. Results Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs (p = 0.0239; OR = 7.571; 95% CI: 1.192–81.46). No association was found between age (p = 0.1996), gender (p = 0.7111) or differentiation status (p > 0.9999) and MCPyV presence in HNSCCs. Conclusions MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs.https://doi.org/10.1186/s13027-020-0276-zCancerHead and neckPolyomavirus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan P. Muñoz Rancés Blanco Julio C. Osorio Carolina Oliva María José Diaz Diego Carrillo-Beltrán Rebeca Aguayo Andrés Castillo Julio C. Tapia Gloria M. Calaf Aldo Gaggero Francisco Aguayo |
spellingShingle |
Juan P. Muñoz Rancés Blanco Julio C. Osorio Carolina Oliva María José Diaz Diego Carrillo-Beltrán Rebeca Aguayo Andrés Castillo Julio C. Tapia Gloria M. Calaf Aldo Gaggero Francisco Aguayo Merkel cell polyomavirus detected in head and neck carcinomas from Chile Infectious Agents and Cancer Cancer Head and neck Polyomavirus |
author_facet |
Juan P. Muñoz Rancés Blanco Julio C. Osorio Carolina Oliva María José Diaz Diego Carrillo-Beltrán Rebeca Aguayo Andrés Castillo Julio C. Tapia Gloria M. Calaf Aldo Gaggero Francisco Aguayo |
author_sort |
Juan P. Muñoz |
title |
Merkel cell polyomavirus detected in head and neck carcinomas from Chile |
title_short |
Merkel cell polyomavirus detected in head and neck carcinomas from Chile |
title_full |
Merkel cell polyomavirus detected in head and neck carcinomas from Chile |
title_fullStr |
Merkel cell polyomavirus detected in head and neck carcinomas from Chile |
title_full_unstemmed |
Merkel cell polyomavirus detected in head and neck carcinomas from Chile |
title_sort |
merkel cell polyomavirus detected in head and neck carcinomas from chile |
publisher |
BMC |
series |
Infectious Agents and Cancer |
issn |
1750-9378 |
publishDate |
2020-01-01 |
description |
Abstract Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects. Methods One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed. Results Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs (p = 0.0239; OR = 7.571; 95% CI: 1.192–81.46). No association was found between age (p = 0.1996), gender (p = 0.7111) or differentiation status (p > 0.9999) and MCPyV presence in HNSCCs. Conclusions MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs. |
topic |
Cancer Head and neck Polyomavirus |
url |
https://doi.org/10.1186/s13027-020-0276-z |
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