Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway

This study investigated the effects of tempeh on the cognitive and antioxidant status in senescence-accelerated mouse prone 8 (SAMP8) mice. Six-month-old SAMP8 mice were divided into one control and three tempeh groups; the tempeh groups were administered 300, 600, and 900 mg/kg body weight (BW) tem...

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Main Authors:	Yin-Ching Chan, I-Te Lee, Ming-Fu Wang, Wen-Chin Yeh, Bi-Chun Liang
Format:	Article
Language:	English
Published:	Elsevier 2018-11-01
Series:	Journal of Functional Foods
Subjects:	Tempeh Senescence acceleration–prone mice Cognitive Antioxidant Amyloid β
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464618304997

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spelling	doaj-4883e2293a96426caafa31df0e12a0bf2021-04-30T07:14:46ZengElsevierJournal of Functional Foods1756-46462018-11-0150112119Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathwayYin-Ching Chan0I-Te Lee1Ming-Fu Wang2Wen-Chin Yeh3Bi-Chun Liang4Department of Food and Nutrition, Providence University, Taiwan; Corresponding author at: Department of Food and Nutrition, Providence University, No. 200, Sec.7, Taiwan Boulevard, Shalu District, Taichung City 43301, Taiwan.Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Food and Nutrition, Providence University, TaiwanDepartment of Food and Nutrition, Providence University, TaiwanDepartment of Food and Nutrition, Providence University, TaiwanThis study investigated the effects of tempeh on the cognitive and antioxidant status in senescence-accelerated mouse prone 8 (SAMP8) mice. Six-month-old SAMP8 mice were divided into one control and three tempeh groups; the tempeh groups were administered 300, 600, and 900 mg/kg body weight (BW) tempeh. The results revealed tempeh groups had stronger cognitive ability, lower malondialdehyde and carbonyl protein levels, and higher superoxide dismutase (SOD) and catalase (CAT) activities in the hippocampus, striatum, and cortex. Of them, the 900 mg/kg BW tempeh showed the most superior results on increasing SOD and CAT mRNA expressions and reducing amyloid β (Aβ) and β-site amyloid precursor protein cleaving enzyme 1 levels; it also increased nuclear factor erythroid 2-related factor 2 (Nrf2) levels by reducing p-p38 and p-JNK expression. In conclusion, tempeh may protect neurons against oxidative stress and Aβ-induced damage and reduce memory impairment by modulating Nrf2 via mitogen-activated protein kinase pathway.http://www.sciencedirect.com/science/article/pii/S1756464618304997TempehSenescence acceleration–prone miceCognitiveAntioxidantAmyloid β
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yin-Ching Chan I-Te Lee Ming-Fu Wang Wen-Chin Yeh Bi-Chun Liang
spellingShingle	Yin-Ching Chan I-Te Lee Ming-Fu Wang Wen-Chin Yeh Bi-Chun Liang Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway Journal of Functional Foods Tempeh Senescence acceleration–prone mice Cognitive Antioxidant Amyloid β
author_facet	Yin-Ching Chan I-Te Lee Ming-Fu Wang Wen-Chin Yeh Bi-Chun Liang
author_sort	Yin-Ching Chan
title	Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
title_short	Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
title_full	Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
title_fullStr	Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
title_full_unstemmed	Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
title_sort	tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating nrf2 expression via mapk pathway
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2018-11-01
description	This study investigated the effects of tempeh on the cognitive and antioxidant status in senescence-accelerated mouse prone 8 (SAMP8) mice. Six-month-old SAMP8 mice were divided into one control and three tempeh groups; the tempeh groups were administered 300, 600, and 900 mg/kg body weight (BW) tempeh. The results revealed tempeh groups had stronger cognitive ability, lower malondialdehyde and carbonyl protein levels, and higher superoxide dismutase (SOD) and catalase (CAT) activities in the hippocampus, striatum, and cortex. Of them, the 900 mg/kg BW tempeh showed the most superior results on increasing SOD and CAT mRNA expressions and reducing amyloid β (Aβ) and β-site amyloid precursor protein cleaving enzyme 1 levels; it also increased nuclear factor erythroid 2-related factor 2 (Nrf2) levels by reducing p-p38 and p-JNK expression. In conclusion, tempeh may protect neurons against oxidative stress and Aβ-induced damage and reduce memory impairment by modulating Nrf2 via mitogen-activated protein kinase pathway.
topic	Tempeh Senescence acceleration–prone mice Cognitive Antioxidant Amyloid β
url	http://www.sciencedirect.com/science/article/pii/S1756464618304997
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Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway

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