Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment
Introduction: Lobar intracerebral haemorrhage (LICH) is a rare cause of stroke which accounts for about 20% of primary intracerebral haemorrhages. The most common causes are cerebral amyloid angiopathy (CAA), high blood pressure and others, such as using antiplatelet or anticoagulation agents.We ana...
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Elsevier España
2012-09-01
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Series: | Neurología (English Edition) |
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English |
format |
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DOAJ |
author |
J. Romero López J.L. Maciñeiras Montero M. Fontanillo Fontanillo D. Escriche Jaime M.J. Moreno Carretero E. Corredera García |
spellingShingle |
J. Romero López J.L. Maciñeiras Montero M. Fontanillo Fontanillo D. Escriche Jaime M.J. Moreno Carretero E. Corredera García Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment Neurología (English Edition) |
author_facet |
J. Romero López J.L. Maciñeiras Montero M. Fontanillo Fontanillo D. Escriche Jaime M.J. Moreno Carretero E. Corredera García |
author_sort |
J. Romero López |
title |
Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
title_short |
Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
title_full |
Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
title_fullStr |
Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
title_full_unstemmed |
Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
title_sort |
lobar intracerebral haemorrhage: analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment |
publisher |
Elsevier España |
series |
Neurología (English Edition) |
issn |
2173-5808 |
publishDate |
2012-09-01 |
description |
Introduction: Lobar intracerebral haemorrhage (LICH) is a rare cause of stroke which accounts for about 20% of primary intracerebral haemorrhages. The most common causes are cerebral amyloid angiopathy (CAA), high blood pressure and others, such as using antiplatelet or anticoagulation agents.We analysed a series of patients with LICH and compared it with subgroups of patients with LICH who were previously receiving antiplatelet or anticoagulation agents. We determined the volume of the bleeding and its predictive value for mortality. Patients and methods: We consecutively and retrospectively included 162 patients diagnosed with LICH and cared for in the Neurology Department of Hospital Meixoeiro in Vigo between 1991 and 2009. We collected demographic characteristics, risk factors, aetiologies and symptoms, and conducted a comparative analysis between the general series and the subgroups of patients receiving anticoagulation and antiplatelet agents. Results: In the general series, the most common cause was possible or probable CAA followed by hypertension. In the subgroup of patients receiving antiplatelet or anticoagulation agents there were no differences in the variables studied, except for the frequency of heart disease. Nonetheless, there were differences with respect to age, heart disease and bleeding volume between the general series (patients not treated with antiplatelet or anticoagulation agents) when compared with the subgroups of patients receiving antiplatelet and anticoagulation agents. Conclusions: We provide new information regarding the clinical behaviour of LICH and its differences in patients receiving antiplatelet or anticoagulation agents. Mortality is higher in cases of LICH on anticoagulants. Female sex and the volume of bleeding are predictors of mortality. Resumen: Introducción: La hemorragia intracerebral lobular (HIL) es una causa poco frecuente de ictus y representan cerca del 20% de las hemorragias intracerebrales primarias. La causa más frecuente son la angiopatía amiloidea cerebral (AAC), la hipertensión arterial (HTA) y otras como el tratamiento antiagregante o anticoagulante.Analizar una serie de pacientes con HIL y compararla con subgrupos de pacientes con HIL antiagregados o anticoagulados previamente. Determinar el volumen de la hemorragia y su valor predictivo de mortalidad. Pacientes y métodos: Se incluyó de forma consecutiva y retrospectiva a 162 pacientes diagnosticados de HIL y atendidos en el servicio de neurología del Hospital Meixoeiro de Vigo entre los años 1991 y 2009. Se recogieron características demográficas, factores de riesgo, etiologías y clínica, y se realizó un análisis comparativo entre la serie general y los subgrupos de paciente antiagregados y anticoagulados. Resultados: En la serie general la causa más frecuente fue la AAC posible o probable seguida de la HTA. En los subgrupos de pacientes antiagregados o anticoagulados no había diferencias en las variables estudiadas excepto en la frecuencia de cardiopatía. Sí existían diferencias en cuanto a la edad, la cardiopatía y la volumen de la hemorragia entre la serie general (sin los pacientes antiagregados o anticoagulados) cuando se compararon con los subgrupos de antiagregados y anticoagulados. Conclusiones: Aportamos algunas novedades respecto al comportamiento clínico de la HIL y sus diferencias en los pacientes antiagregados o anticoagulados. La mortalidad es superior en las HIL anticoaguladas. Son variables predictivas de defunción el sexo femenino y el volumen de la hemorragia. Keywords: Anticoagulation, Antiplatelet, Lobar intracerebral haemorrhage, Prognostic variables, Palabras clave: Anticoagulación, Antiagregación, Hemorragia intracerebral lobular, Variables pronósticas |
url |
http://www.sciencedirect.com/science/article/pii/S2173580812001319 |
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doaj-4884014f424c4c95b31351bdac7d7b352020-11-24T21:35:57ZengElsevier EspañaNeurología (English Edition)2173-58082012-09-01277387393Lobar intracerebral haemorrhage: Analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatmentJ. Romero López0J.L. Maciñeiras Montero1M. Fontanillo Fontanillo2D. Escriche Jaime3M.J. Moreno Carretero4E. Corredera García5Sección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, Spain; Corresponding author.Sección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, SpainUnidad de Apoyo a la Investigación, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, SpainSección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, SpainSección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, SpainSección de Neurología, Hospital do Meixoeiro (CHUVI), Vigo, Pontevedra, SpainIntroduction: Lobar intracerebral haemorrhage (LICH) is a rare cause of stroke which accounts for about 20% of primary intracerebral haemorrhages. The most common causes are cerebral amyloid angiopathy (CAA), high blood pressure and others, such as using antiplatelet or anticoagulation agents.We analysed a series of patients with LICH and compared it with subgroups of patients with LICH who were previously receiving antiplatelet or anticoagulation agents. We determined the volume of the bleeding and its predictive value for mortality. Patients and methods: We consecutively and retrospectively included 162 patients diagnosed with LICH and cared for in the Neurology Department of Hospital Meixoeiro in Vigo between 1991 and 2009. We collected demographic characteristics, risk factors, aetiologies and symptoms, and conducted a comparative analysis between the general series and the subgroups of patients receiving anticoagulation and antiplatelet agents. Results: In the general series, the most common cause was possible or probable CAA followed by hypertension. In the subgroup of patients receiving antiplatelet or anticoagulation agents there were no differences in the variables studied, except for the frequency of heart disease. Nonetheless, there were differences with respect to age, heart disease and bleeding volume between the general series (patients not treated with antiplatelet or anticoagulation agents) when compared with the subgroups of patients receiving antiplatelet and anticoagulation agents. Conclusions: We provide new information regarding the clinical behaviour of LICH and its differences in patients receiving antiplatelet or anticoagulation agents. Mortality is higher in cases of LICH on anticoagulants. Female sex and the volume of bleeding are predictors of mortality. Resumen: Introducción: La hemorragia intracerebral lobular (HIL) es una causa poco frecuente de ictus y representan cerca del 20% de las hemorragias intracerebrales primarias. La causa más frecuente son la angiopatía amiloidea cerebral (AAC), la hipertensión arterial (HTA) y otras como el tratamiento antiagregante o anticoagulante.Analizar una serie de pacientes con HIL y compararla con subgrupos de pacientes con HIL antiagregados o anticoagulados previamente. Determinar el volumen de la hemorragia y su valor predictivo de mortalidad. Pacientes y métodos: Se incluyó de forma consecutiva y retrospectiva a 162 pacientes diagnosticados de HIL y atendidos en el servicio de neurología del Hospital Meixoeiro de Vigo entre los años 1991 y 2009. Se recogieron características demográficas, factores de riesgo, etiologías y clínica, y se realizó un análisis comparativo entre la serie general y los subgrupos de paciente antiagregados y anticoagulados. Resultados: En la serie general la causa más frecuente fue la AAC posible o probable seguida de la HTA. En los subgrupos de pacientes antiagregados o anticoagulados no había diferencias en las variables estudiadas excepto en la frecuencia de cardiopatía. Sí existían diferencias en cuanto a la edad, la cardiopatía y la volumen de la hemorragia entre la serie general (sin los pacientes antiagregados o anticoagulados) cuando se compararon con los subgrupos de antiagregados y anticoagulados. Conclusiones: Aportamos algunas novedades respecto al comportamiento clínico de la HIL y sus diferencias en los pacientes antiagregados o anticoagulados. La mortalidad es superior en las HIL anticoaguladas. Son variables predictivas de defunción el sexo femenino y el volumen de la hemorragia. Keywords: Anticoagulation, Antiplatelet, Lobar intracerebral haemorrhage, Prognostic variables, Palabras clave: Anticoagulación, Antiagregación, Hemorragia intracerebral lobular, Variables pronósticashttp://www.sciencedirect.com/science/article/pii/S2173580812001319 |