Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β

Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β

Objective. This study aimed to evaluate the protective effect of kaempferol against myocardial ischemia/reperfusion (I/R) injury in rats. Method. Left ventricular developed pressure (LVDP) and its maximum up/down rate (±dp/dtmax) were recorded as myocardial function. Infarct size was detected with 2...

Full description

Bibliographic Details
Main Authors:	Mingjie Zhou, Huanhuan Ren, Jichun Han, Wenjuan Wang, Qiusheng Zheng, Dong Wang
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2015/481405

Similar Items

The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury
by: Mei Li, et al.
Published: (2020-01-01)

Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart
by: Daoxu Qu, et al.
Published: (2016-01-01)

Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity
by: Karthi Shanmugam, et al.
Published: (2018-01-01)

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus
by: Bo Zhao, et al.
Published: (2017-01-01)

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury
by: Tetsuji Miura, et al.
Published: (2009-01-01)

Glycogen synthase kinase-3? (GSK3?) inhibition by kaempferol mediates the anti-hyperglycaemic effect of Gynura procumbens
by: Wong, S.K, et al.
Published: (2015)

Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2
by: Defang Li, et al.
Published: (2018-01-01)

Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice
by: Shailendra P. Singh, et al.
Published: (2015-08-01)

Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats
by: Xiaohua Shen, et al.
Published: (2017-06-01)

Carbon Monoxide Protects against Hepatic Ischemia/Reperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β
by: Hyo Jeong Kim, et al.
Published: (2013-01-01)

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain
by: A. N. Kuzovlev, et al.
Published: (2021-01-01)

Glycogen Synthase Kinase-3
by: Peter Crouch, et al.
Published: (2011-01-01)

Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
by: Takahiro Domoto, et al.
Published: (2020-06-01)

Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury
by: Kapil Suchal, et al.
Published: (2016-01-01)

Cardioprotection against Ischemia/Reperfusion by Licochalcone B in Isolated Rat Hearts
by: Jichun Han, et al.
Published: (2014-01-01)

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway
by: Dong Wang, et al.
Published: (2017-01-01)

Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury
by: Dong Wang, et al.
Published: (2014-01-01)

Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer
by: Takeo Shimasaki, et al.
Published: (2012-01-01)

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
by: Daniela Hulcová, et al.
Published: (2018-03-01)

THE EFFECT OF GLYCOGEN SYNTHASE KINASE-3β ON THE VASCULAR DEVELOPMENT IN ZEBRAFISH
by: Yen-Ting Lai, et al.
Published: (2006)

Corrigendum to “Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury”
by: Kapil Suchal, et al.
Published: (2020-01-01)

Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion.
by: Qifei Zou, et al.
Published: (2013-01-01)

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains
by: Ambika Krishnankutty, et al.
Published: (2017-08-01)

Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer's Disease?
by: Jari Koistinaho, et al.
Published: (2011-01-01)

Functional Role of Glycogen synthase Kinase-3β on Glucocorticoid-mediated signaling
by: Rubio Patiño, Camila
Published: (2012)

The Effect of Glycogen Synthase Kinase 3β on the Angiogenesis during Zebrafish Embryogenesis
by: Yi-Zhen Lin, et al.
Published: (2010)

Glycogen synthase kinase 3β induces Warburg effect in glioma cells
by: Chih-Hsun Wu, et al.
Published: (2010)

Molecular docking study of xylogranatins binding to glycogen synthase kinase-3β
by: Bailly, C., et al.
Published: (2022)

Effect of Preconditioning with Desflurane on Phosphorylated Glycogen Synthase Kinase 3β Contents in an Experiment
by: V. V. Likhvantsev, et al.
Published: (2017-01-01)

Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
by: Seong-Ho Koh, et al.
Published: (2011-01-01)

Glycogen Synthase Kinase-3β: An Investigation Of The Novel Serine 389 Phosphorylation Site
by: Hare, Brendan Deegan
Published: (2015)

Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma
by: Jichun Han, et al.
Published: (2017-07-01)

Apoptotic Role of Glycogen Synthase Kinase-3 in Leukemia
by: Wei-ChingHuang, et al.
Published: (2011)

Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced Apoptosis
by: Jing Wang, et al.
Published: (2020-04-01)

Alternative splicing of the porcine glycogen synthase kinase 3β (GSK-3β) gene with differential expression patterns and regulatory functions.
by: Linjie Wang, et al.
Published: (2012-01-01)

Glycogen synthase kinase-3β inhibitor ameliorates imbalance of connexin 43 in an acute kidney injury model
by: Yini Wang, et al.
Published: (2015-01-01)

Multiple tasks of Glycogen synthase kinase-3beta (GSK-3β ) and its partners
by: Ching-chih Lin, et al.
Published: (2007)

Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β
by: Yingui Li, et al.
Published: (2020-01-01)

The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord
by: Mina Rashvand, et al.
Published: (2020-01-01)

Glycogen Synthase Kinase 3β Inhibition as a Therapeutic Approach in the Treatment of Endometrial Cancer
by: Liang Ma, et al.
Published: (2013-08-01)

Cannot write session to /tmp/vufind_sessions/sess_ig8qrqhvao5dpeev886isfj6b7