Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas
Soft tissue sarcoma (STS) of the extremities is typically treated with limb-sparing surgery and radiation therapy; with this treatment approach, high local control rates can be achieved. However, postradiation bone fractures, fractures occurring in the prior radiation field with minimal or no trauma...
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Hindawi Limited
2021-01-01
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Series: | Sarcoma |
Online Access: | http://dx.doi.org/10.1155/2021/8877567 |
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doaj-488c78750435431ca22b041ac096c0b02021-03-29T00:08:40ZengHindawi LimitedSarcoma1369-16432021-01-01202110.1155/2021/8877567Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue SarcomasMeredith K. Bartelstein0Divya Yerramilli1Alexander B. Christ2Shachar Kenan3Koichi Ogura4Tomohiro Fujiwara5Nicola Fabbri6John H. Healey7Department of SurgeryDepartment of Radiation OncologyDepartment of SurgeryDepartment of SurgeryDepartment of SurgeryDepartment of SurgeryDepartment of SurgeryDepartment of SurgerySoft tissue sarcoma (STS) of the extremities is typically treated with limb-sparing surgery and radiation therapy; with this treatment approach, high local control rates can be achieved. However, postradiation bone fractures, fractures occurring in the prior radiation field with minimal or no trauma, are a serious late complication that occurs in 2–22% of patients who receive surgery and radiation for STS. Multiple risk factors for sustaining a postradiation fracture exist, including high radiation dose, female sex, periosteal stripping, older age, femur location, and chemotherapy administration. The treatment of these pathological fractures can be difficult, with complications including delayed union, nonunion, and infection posing particular challenges. Here, we review the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients.http://dx.doi.org/10.1155/2021/8877567 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meredith K. Bartelstein Divya Yerramilli Alexander B. Christ Shachar Kenan Koichi Ogura Tomohiro Fujiwara Nicola Fabbri John H. Healey |
spellingShingle |
Meredith K. Bartelstein Divya Yerramilli Alexander B. Christ Shachar Kenan Koichi Ogura Tomohiro Fujiwara Nicola Fabbri John H. Healey Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas Sarcoma |
author_facet |
Meredith K. Bartelstein Divya Yerramilli Alexander B. Christ Shachar Kenan Koichi Ogura Tomohiro Fujiwara Nicola Fabbri John H. Healey |
author_sort |
Meredith K. Bartelstein |
title |
Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas |
title_short |
Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas |
title_full |
Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas |
title_fullStr |
Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas |
title_full_unstemmed |
Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas |
title_sort |
postradiation fractures after combined modality treatment in extremity soft tissue sarcomas |
publisher |
Hindawi Limited |
series |
Sarcoma |
issn |
1369-1643 |
publishDate |
2021-01-01 |
description |
Soft tissue sarcoma (STS) of the extremities is typically treated with limb-sparing surgery and radiation therapy; with this treatment approach, high local control rates can be achieved. However, postradiation bone fractures, fractures occurring in the prior radiation field with minimal or no trauma, are a serious late complication that occurs in 2–22% of patients who receive surgery and radiation for STS. Multiple risk factors for sustaining a postradiation fracture exist, including high radiation dose, female sex, periosteal stripping, older age, femur location, and chemotherapy administration. The treatment of these pathological fractures can be difficult, with complications including delayed union, nonunion, and infection posing particular challenges. Here, we review the mechanisms, risk factors, and treatment challenges associated with postradiation fractures in STS patients. |
url |
http://dx.doi.org/10.1155/2021/8877567 |
work_keys_str_mv |
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