Transcriptional Regulation of Dental Epithelial Cell Fate
Dental enamel is hardest tissue in the body and is produced by dental epithelial cells residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are facilitated by fate determining transcription factors and chromatin regulators. Understanding the transcriptional...
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doaj-488ccb6ebda046ff955d6a5b5705f0a42020-11-27T08:03:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218952895210.3390/ijms21238952Transcriptional Regulation of Dental Epithelial Cell FateKeigo Yoshizaki0Satoshi Fukumoto1Daniel D. Bikle2Yuko Oda3Section of Orthodontics and Dentofacial Orthopedics, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, JapanSection of Pediatric Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, JapanDepartments of Medicine and Endocrinology, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94158, USADepartments of Medicine and Endocrinology, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA 94158, USADental enamel is hardest tissue in the body and is produced by dental epithelial cells residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are facilitated by fate determining transcription factors and chromatin regulators. Understanding the transcriptional program controlling dental cell fate is critical for our efforts to build and repair teeth. In this review, we describe the current understanding of these regulators essential for regeneration of dental epithelial stem cells and progeny, which are identified through transgenic mouse models. We first describe the development and morphogenesis of mouse dental epithelium in which different subpopulations of epithelia such as ameloblasts contribute to enamel formation. Then, we describe the function of critical factors in stem cells or progeny to drive enamel lineages. We also show that gene mutations of these factors are associated with dental anomalies in craniofacial diseases in humans. We also describe the function of the master regulators to govern dental lineages, in which the genetic removal of each factor switches dental cell fate to that generating hair. The distinct and related mechanisms responsible for the lineage plasticity are discussed. This knowledge will lead us to develop a potential tool for bioengineering new teeth.https://www.mdpi.com/1422-0067/21/23/8952transcriptiontranscription factorstem cellcell fatelineagedental epithelia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keigo Yoshizaki Satoshi Fukumoto Daniel D. Bikle Yuko Oda |
spellingShingle |
Keigo Yoshizaki Satoshi Fukumoto Daniel D. Bikle Yuko Oda Transcriptional Regulation of Dental Epithelial Cell Fate International Journal of Molecular Sciences transcription transcription factor stem cell cell fate lineage dental epithelia |
author_facet |
Keigo Yoshizaki Satoshi Fukumoto Daniel D. Bikle Yuko Oda |
author_sort |
Keigo Yoshizaki |
title |
Transcriptional Regulation of Dental Epithelial Cell Fate |
title_short |
Transcriptional Regulation of Dental Epithelial Cell Fate |
title_full |
Transcriptional Regulation of Dental Epithelial Cell Fate |
title_fullStr |
Transcriptional Regulation of Dental Epithelial Cell Fate |
title_full_unstemmed |
Transcriptional Regulation of Dental Epithelial Cell Fate |
title_sort |
transcriptional regulation of dental epithelial cell fate |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
Dental enamel is hardest tissue in the body and is produced by dental epithelial cells residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are facilitated by fate determining transcription factors and chromatin regulators. Understanding the transcriptional program controlling dental cell fate is critical for our efforts to build and repair teeth. In this review, we describe the current understanding of these regulators essential for regeneration of dental epithelial stem cells and progeny, which are identified through transgenic mouse models. We first describe the development and morphogenesis of mouse dental epithelium in which different subpopulations of epithelia such as ameloblasts contribute to enamel formation. Then, we describe the function of critical factors in stem cells or progeny to drive enamel lineages. We also show that gene mutations of these factors are associated with dental anomalies in craniofacial diseases in humans. We also describe the function of the master regulators to govern dental lineages, in which the genetic removal of each factor switches dental cell fate to that generating hair. The distinct and related mechanisms responsible for the lineage plasticity are discussed. This knowledge will lead us to develop a potential tool for bioengineering new teeth. |
topic |
transcription transcription factor stem cell cell fate lineage dental epithelia |
url |
https://www.mdpi.com/1422-0067/21/23/8952 |
work_keys_str_mv |
AT keigoyoshizaki transcriptionalregulationofdentalepithelialcellfate AT satoshifukumoto transcriptionalregulationofdentalepithelialcellfate AT danieldbikle transcriptionalregulationofdentalepithelialcellfate AT yukooda transcriptionalregulationofdentalepithelialcellfate |
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1724413790288609280 |