<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer
Over the last decades a renewed interest in <i>n</i>−3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects against cancer diseases, including breast carcinoma. These <i>n</...
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doaj-48918247a2234bbc89c1a79af67f8bbf2020-11-25T02:01:49ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01217227910.3390/ijms21072279ijms21072279<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast CancerCinzia Giordano0Pierluigi Plastina1Ines Barone2Stefania Catalano3Daniela Bonofiglio4Department of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, 87036 Arcavacata di Rende, ItalyOver the last decades a renewed interest in <i>n</i>−3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects against cancer diseases, including breast carcinoma. These <i>n</i>−3 PUFAs mainly consist of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that, alone or in combination with anticancer agents, induce cell cycle arrest, autophagy, apoptosis, and tumor growth inhibition. A large number of molecular targets of <i>n</i>−3 PUFAs have been identified and multiple mechanisms appear to underlie their antineoplastic activities. Evidence exists that EPA and DHA also elicit anticancer effects by the conversion to their corresponding ethanolamide derivatives in cancer cells, by binding and activation of different receptors and distinct signaling pathways. Other conjugates with serotonin or dopamine have been found to exert anti-inflammatory activities in breast tumor microenvironment, indicating the importance of these compounds as modulators of tumor epithelial/stroma interplay. The objective of this review is to provide a general overview and an update of the current <i>n</i>−3 PUFA derivative research and to highlight intriguing aspects of the potential therapeutic benefits of these low-toxicity compounds in breast cancer treatment and care.https://www.mdpi.com/1422-0067/21/7/2279omega−3 polyunsaturated fatty acidsomega−3 polyunsaturated fatty acid derivativesomega−3 polyunsaturated fatty acid conjugatesomega−3 polyunsaturated fatty acid amidesbreast cancercannabinoid receptorsperoxisome proliferator-activated receptor gamma |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cinzia Giordano Pierluigi Plastina Ines Barone Stefania Catalano Daniela Bonofiglio |
spellingShingle |
Cinzia Giordano Pierluigi Plastina Ines Barone Stefania Catalano Daniela Bonofiglio <i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer International Journal of Molecular Sciences omega−3 polyunsaturated fatty acids omega−3 polyunsaturated fatty acid derivatives omega−3 polyunsaturated fatty acid conjugates omega−3 polyunsaturated fatty acid amides breast cancer cannabinoid receptors peroxisome proliferator-activated receptor gamma |
author_facet |
Cinzia Giordano Pierluigi Plastina Ines Barone Stefania Catalano Daniela Bonofiglio |
author_sort |
Cinzia Giordano |
title |
<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer |
title_short |
<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer |
title_full |
<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer |
title_fullStr |
<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer |
title_full_unstemmed |
<i>n</i>–3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer |
title_sort |
<i>n</i>–3 polyunsaturated fatty acid amides: new avenues in the prevention and treatment of breast cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-03-01 |
description |
Over the last decades a renewed interest in <i>n</i>−3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects against cancer diseases, including breast carcinoma. These <i>n</i>−3 PUFAs mainly consist of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that, alone or in combination with anticancer agents, induce cell cycle arrest, autophagy, apoptosis, and tumor growth inhibition. A large number of molecular targets of <i>n</i>−3 PUFAs have been identified and multiple mechanisms appear to underlie their antineoplastic activities. Evidence exists that EPA and DHA also elicit anticancer effects by the conversion to their corresponding ethanolamide derivatives in cancer cells, by binding and activation of different receptors and distinct signaling pathways. Other conjugates with serotonin or dopamine have been found to exert anti-inflammatory activities in breast tumor microenvironment, indicating the importance of these compounds as modulators of tumor epithelial/stroma interplay. The objective of this review is to provide a general overview and an update of the current <i>n</i>−3 PUFA derivative research and to highlight intriguing aspects of the potential therapeutic benefits of these low-toxicity compounds in breast cancer treatment and care. |
topic |
omega−3 polyunsaturated fatty acids omega−3 polyunsaturated fatty acid derivatives omega−3 polyunsaturated fatty acid conjugates omega−3 polyunsaturated fatty acid amides breast cancer cannabinoid receptors peroxisome proliferator-activated receptor gamma |
url |
https://www.mdpi.com/1422-0067/21/7/2279 |
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