Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that the postulated substrate specifying role of C-...

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Main Authors:	Mark J. Calcott, Jeremy G. Owen, David F. Ackerley
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18365-0

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spelling	doaj-48924e1b8e5f493994a0d6dff8b818742021-09-12T11:48:32ZengNature Publishing GroupNature Communications2041-17232020-09-0111111010.1038/s41467-020-18365-0Efficient rational modification of non-ribosomal peptides by adenylation domain substitutionMark J. Calcott0Jeremy G. Owen1David F. Ackerley2School of Biological Sciences, Victoria University of WellingtonSchool of Biological Sciences, Victoria University of WellingtonSchool of Biological Sciences, Victoria University of WellingtonNon-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that the postulated substrate specifying role of C-domains may be rare in nature.https://doi.org/10.1038/s41467-020-18365-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mark J. Calcott Jeremy G. Owen David F. Ackerley
spellingShingle	Mark J. Calcott Jeremy G. Owen David F. Ackerley Efficient rational modification of non-ribosomal peptides by adenylation domain substitution Nature Communications
author_facet	Mark J. Calcott Jeremy G. Owen David F. Ackerley
author_sort	Mark J. Calcott
title	Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
title_short	Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
title_full	Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
title_fullStr	Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
title_full_unstemmed	Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
title_sort	efficient rational modification of non-ribosomal peptides by adenylation domain substitution
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that the postulated substrate specifying role of C-domains may be rare in nature.
url	https://doi.org/10.1038/s41467-020-18365-0
work_keys_str_mv	AT markjcalcott efficientrationalmodificationofnonribosomalpeptidesbyadenylationdomainsubstitution AT jeremygowen efficientrationalmodificationofnonribosomalpeptidesbyadenylationdomainsubstitution AT davidfackerley efficientrationalmodificationofnonribosomalpeptidesbyadenylationdomainsubstitution
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Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

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