MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila

MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila

Accumulating evidence suggests that microRNAs play a role in circadian regulation. Here the authors show that in theDrosophila brain, mir-92a suppresses the excitability of PDF neurons—key circadian pacemaker cells in Drosophila—via inhibiting the translation of its target sirt2.

Bibliographic Details
Main Authors: Xiao Chen, Michael Rosbash
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14707
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spelling doaj-489b58bf499f4508a9634b2675dbbd1d2021-05-11T07:50:06ZengNature Publishing GroupNature Communications2041-17232017-03-018111110.1038/ncomms14707MicroRNA-92a is a circadian modulator of neuronal excitability in DrosophilaXiao Chen0Michael Rosbash1Department of Biology, Howard Hughes Medical Institute and National Center for Behavioral Genomics, Brandeis UniversityDepartment of Biology, Howard Hughes Medical Institute and National Center for Behavioral Genomics, Brandeis UniversityAccumulating evidence suggests that microRNAs play a role in circadian regulation. Here the authors show that in theDrosophila brain, mir-92a suppresses the excitability of PDF neurons—key circadian pacemaker cells in Drosophila—via inhibiting the translation of its target sirt2.https://doi.org/10.1038/ncomms14707
collection DOAJ
language English
format Article
sources DOAJ
author Xiao Chen
Michael Rosbash
spellingShingle Xiao Chen
Michael Rosbash
MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
Nature Communications
author_facet Xiao Chen
Michael Rosbash
author_sort Xiao Chen
title MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
title_short MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
title_full MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
title_fullStr MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
title_full_unstemmed MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
title_sort microrna-92a is a circadian modulator of neuronal excitability in drosophila
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-03-01
description Accumulating evidence suggests that microRNAs play a role in circadian regulation. Here the authors show that in theDrosophila brain, mir-92a suppresses the excitability of PDF neurons—key circadian pacemaker cells in Drosophila—via inhibiting the translation of its target sirt2.
url https://doi.org/10.1038/ncomms14707
work_keys_str_mv AT xiaochen microrna92aisacircadianmodulatorofneuronalexcitabilityindrosophila
AT michaelrosbash microrna92aisacircadianmodulatorofneuronalexcitabilityindrosophila
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