Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice
We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mi...
Main Authors: | Tyler T Wright, Rachel V. Jimenez, Todd E. Morgan, Namrata Bali, Xiaogang Hou, Mark A. McCrory, Caleb E. Finch, Alexander J. Szalai |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
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Series: | Autoimmune Diseases |
Online Access: | http://dx.doi.org/10.1155/2015/640171 |
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