Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications
Abstract Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in...
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Online Access: | https://doi.org/10.1186/s12933-020-01200-7 |
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doaj-48ad3ffa3b7643a2bdd80308f63f879d2021-01-10T12:39:18ZengBMCCardiovascular Diabetology1475-28402021-01-0120111310.1186/s12933-020-01200-7Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complicationsBao Sun0Zhiying Luo1Jiecan Zhou2Department of Pharmacy, The Second Xiangya Hospital, Central South UniversityDepartment of Pharmacy, The Second Xiangya Hospital, Central South UniversityInstitute of Clinical Medicine, The First Affiliated Hospital, University of South ChinaAbstract Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.https://doi.org/10.1186/s12933-020-01200-7Glycemic variabilityDiabetes mellitusDiabetic macrovascular and microvascular complicationsTherapeutic strategies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bao Sun Zhiying Luo Jiecan Zhou |
spellingShingle |
Bao Sun Zhiying Luo Jiecan Zhou Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications Cardiovascular Diabetology Glycemic variability Diabetes mellitus Diabetic macrovascular and microvascular complications Therapeutic strategies |
author_facet |
Bao Sun Zhiying Luo Jiecan Zhou |
author_sort |
Bao Sun |
title |
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
title_short |
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
title_full |
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
title_fullStr |
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
title_full_unstemmed |
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
title_sort |
comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2021-01-01 |
description |
Abstract Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus. |
topic |
Glycemic variability Diabetes mellitus Diabetic macrovascular and microvascular complications Therapeutic strategies |
url |
https://doi.org/10.1186/s12933-020-01200-7 |
work_keys_str_mv |
AT baosun comprehensiveelaborationofglycemicvariabilityindiabeticmacrovascularandmicrovascularcomplications AT zhiyingluo comprehensiveelaborationofglycemicvariabilityindiabeticmacrovascularandmicrovascularcomplications AT jiecanzhou comprehensiveelaborationofglycemicvariabilityindiabeticmacrovascularandmicrovascularcomplications |
_version_ |
1724342420210974720 |