Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-07-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/19/7/1979 |
id |
doaj-48adf831ab024530bc1778deec8349a5 |
---|---|
record_format |
Article |
spelling |
doaj-48adf831ab024530bc1778deec8349a52020-11-25T00:22:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-07-01197197910.3390/ijms19071979ijms19071979Gold Nanoparticles in Diagnostics and Therapeutics for Human CancerPriyanka Singh0Santosh Pandit1V.R.S.S. Mokkapati2Abhroop Garg3Vaishnavi Ravikumar4Ivan Mijakovic5The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, DenmarkSystems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Chalmers, SwedenSystems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Chalmers, SwedenThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, DenmarkThe application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications. These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature. Moreover, the non-toxic and non-immunogenic nature of gold nanoparticles and the high permeability and retention effect provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Various innovative approaches with gold nanoparticles are under development. In this review, we provide an overview of recent progress made in the application of gold nanoparticles in the treatment of cancer by tumor detection, drug delivery, imaging, photothermal and photodynamic therapy and their current limitations in terms of bioavailability and the fate of the nanoparticles.http://www.mdpi.com/1422-0067/19/7/1979gold nanoparticlescancerprotein coronabiocompatibilityphotoimagingdrug deliveryphotothermal therapyphotodynamic therapyclinical trialstoxicology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Priyanka Singh Santosh Pandit V.R.S.S. Mokkapati Abhroop Garg Vaishnavi Ravikumar Ivan Mijakovic |
spellingShingle |
Priyanka Singh Santosh Pandit V.R.S.S. Mokkapati Abhroop Garg Vaishnavi Ravikumar Ivan Mijakovic Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer International Journal of Molecular Sciences gold nanoparticles cancer protein corona biocompatibility photoimaging drug delivery photothermal therapy photodynamic therapy clinical trials toxicology |
author_facet |
Priyanka Singh Santosh Pandit V.R.S.S. Mokkapati Abhroop Garg Vaishnavi Ravikumar Ivan Mijakovic |
author_sort |
Priyanka Singh |
title |
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer |
title_short |
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer |
title_full |
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer |
title_fullStr |
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer |
title_full_unstemmed |
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer |
title_sort |
gold nanoparticles in diagnostics and therapeutics for human cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-07-01 |
description |
The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as a potential tool for diagnosis of various cancers and for drug delivery applications. These properties include high surface area to volume ratio, surface plasmon resonance, surface chemistry and multi-functionalization, facile synthesis, and stable nature. Moreover, the non-toxic and non-immunogenic nature of gold nanoparticles and the high permeability and retention effect provide additional benefits by enabling easy penetration and accumulation of drugs at the tumor sites. Various innovative approaches with gold nanoparticles are under development. In this review, we provide an overview of recent progress made in the application of gold nanoparticles in the treatment of cancer by tumor detection, drug delivery, imaging, photothermal and photodynamic therapy and their current limitations in terms of bioavailability and the fate of the nanoparticles. |
topic |
gold nanoparticles cancer protein corona biocompatibility photoimaging drug delivery photothermal therapy photodynamic therapy clinical trials toxicology |
url |
http://www.mdpi.com/1422-0067/19/7/1979 |
work_keys_str_mv |
AT priyankasingh goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer AT santoshpandit goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer AT vrssmokkapati goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer AT abhroopgarg goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer AT vaishnaviravikumar goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer AT ivanmijakovic goldnanoparticlesindiagnosticsandtherapeuticsforhumancancer |
_version_ |
1725358961531551744 |