Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein
Abstract Nucleocytoplasmic transport of signaling modulators is essential for regulating cellular responses to extracellular stimulation and stress, as well as pathogen infection. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), mediates nuclear export of proteins, rRNAs, snRNAs, a...
Main Authors: | Wen Meng, Shou-Jiang Gao |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
|
Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-020-03303-1 |
Similar Items
-
Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system.
by: Dajiang Li, et al.
Published: (2019-02-01) -
KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication
by: Natacha Coen, et al.
Published: (2014-11-01) -
Activation of DNA Damage Response Pathways during Lytic Replication of KSHV
by: Robert Hollingworth, et al.
Published: (2015-06-01) -
Regulation of KSHV Latency and Lytic Reactivation
by: Grant Broussard, et al.
Published: (2020-09-01) -
Molecular Biology of KSHV Lytic Reactivation
by: Pravinkumar Purushothaman, et al.
Published: (2015-01-01)