Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

Abstract Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new squamocolumnar junctions are formed, and p...

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Main Authors: Jobran M. Moshi, Klaas J. Hoogduin, Monique Ummelen, Mieke E. R. Henfling, Manon vanEngeland, Kim A. D. Wouters, Hans Stoop, Imke Demers, Leendert H. J. Looijenga, Frans C. S. Ramaekers, Anton N. H. Hopman
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Cancer Medicine
Subjects:
cervical preneoplasia
keratins
reserve cells
SOX17
SOX2
squamocolumnar junction
Online Access:https://doi.org/10.1002/cam4.3201

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