Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation
Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they ar...
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doaj-48b8542276344751878d22e681894b112021-05-05T21:06:34ZengeLife Sciences Publications LtdeLife2050-084X2020-05-01910.7554/eLife.57010Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidationJosué Haubrich0https://orcid.org/0000-0002-3632-5566Matteo Bernabo1Karim Nader2Department of Psychology, McGill University, Montreal, CanadaDepartment of Neurology and Neurosurgery, McGill University, Montreal, CanadaDepartment of Psychology, McGill University, Montreal, CanadaMemory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we investigated the hypothesis that specific modulatory signals shape memory formation into a state that is reconsolidation-resistant. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala of rats. Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to post-reactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC.https://elifesciences.org/articles/57010fearmemoryamygdalalocus coeruleusreconsolidationnoradrenaline |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Josué Haubrich Matteo Bernabo Karim Nader |
spellingShingle |
Josué Haubrich Matteo Bernabo Karim Nader Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation eLife fear memory amygdala locus coeruleus reconsolidation noradrenaline |
author_facet |
Josué Haubrich Matteo Bernabo Karim Nader |
author_sort |
Josué Haubrich |
title |
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
title_short |
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
title_full |
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
title_fullStr |
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
title_full_unstemmed |
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
title_sort |
noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2020-05-01 |
description |
Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we investigated the hypothesis that specific modulatory signals shape memory formation into a state that is reconsolidation-resistant. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala of rats. Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to post-reactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC. |
topic |
fear memory amygdala locus coeruleus reconsolidation noradrenaline |
url |
https://elifesciences.org/articles/57010 |
work_keys_str_mv |
AT josuehaubrich noradrenergicprojectionsfromthelocuscoeruleustotheamygdalaconstrainfearmemoryreconsolidation AT matteobernabo noradrenergicprojectionsfromthelocuscoeruleustotheamygdalaconstrainfearmemoryreconsolidation AT karimnader noradrenergicprojectionsfromthelocuscoeruleustotheamygdalaconstrainfearmemoryreconsolidation |
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1721458354151227392 |