The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers

Abstract Background Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk fa...

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Main Authors: Huai Heng Loh, Haslinda Taipin, Asri Said
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Obesity Science & Practice
Subjects:
Online Access:https://doi.org/10.1002/osp4.512
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spelling doaj-48b9890c09ac43bc9558485f30a9f0092021-08-07T03:03:16ZengWileyObesity Science & Practice2055-22382021-08-017442543110.1002/osp4.512The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothersHuai Heng Loh0Haslinda Taipin1Asri Said2Faculty of Medicine and Health Sciences Universiti Malaysia Sarawak MalaysiaMalaysia Ministry of Health Training Institute Kota Kinabalu Sabah MalaysiaFaculty of Medicine and Health Sciences Universiti Malaysia Sarawak MalaysiaAbstract Background Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk factor for this adverse outcome. There are no prospective studies on this topic in Malaysia. This study aimed to examine prospectively the effects of obesity in pregnancy and GWG, independent of GDM, on neonatal outcome. Methods Pregnant mothers in the first trimester, who presented to health clinics in Kuching, were screened. Mothers with existing diabetes mellitus or GDM were excluded using 75‐g oral glucose tolerance test during the first and second trimesters. Participants with the first trimester BMI ≥ 23 kg/m2 were recruited as overweight/obese group, whereas those with BMI 18.5–22.9 kg/m2 were taken as the comparison group. At every trimester visit, mothers' weights were recorded. Babies' birth weight and occurrence of adverse neonatal outcome were documented. Results There were 123 mothers recruited as overweight/obese group (mean BMI 29.0 kg/m2 ± 4.45) and 102 mothers as comparison group (mean BMI 20.4 kg/m2 ± 1.48). The number of low birth weight was similar between groups: 9.8% in overweight/obese group, 6.9% in the comparison group (p = 0.416). More than half of these babies were born to mothers with inadequate GWG (58.3% in obese group vs. 57.1% in control group, p = 0.077). There was no significant difference in the mean birth weight (3000 g ± 454.5 vs. 3038 g ± 340.8, p = 0.471), preterm delivery (8.13% vs. 3.92%, p = 0.193), and admission rate to neonatal intensive care unit (8.13% vs. 7.85%, p = 0.937) between groups. There was a positive correlation between the total GWG in overweight/obese group on baby's weight (r = 0.222, p = 0.013). Inadequate GWG was not correlated with lower birth weight (p = 0.052). Conclusions Obesity in pregnancy was not associated with poor neonatal outcome in this small sample of women in Malaysia. Total GWG showed a weak correlation with baby's birth weight in overweight/obese group.https://doi.org/10.1002/osp4.512gestational weight gainglucose‐tolerantneonatal outcomeobesitypregnancy
collection DOAJ
language English
format Article
sources DOAJ
author Huai Heng Loh
Haslinda Taipin
Asri Said
spellingShingle Huai Heng Loh
Haslinda Taipin
Asri Said
The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
Obesity Science & Practice
gestational weight gain
glucose‐tolerant
neonatal outcome
obesity
pregnancy
author_facet Huai Heng Loh
Haslinda Taipin
Asri Said
author_sort Huai Heng Loh
title The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_short The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_full The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_fullStr The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_full_unstemmed The effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
title_sort effect of obesity in pregnancy and gestational weight gain on neonatal outcome in glucose‐tolerant mothers
publisher Wiley
series Obesity Science & Practice
issn 2055-2238
publishDate 2021-08-01
description Abstract Background Most studies showing association between mothers with obesity in pregnancy or excessive gestational weight gain (GWG) and adverse neonatal outcome were cross‐sectional or retrospective. Many included patients are with gestational diabetes mellitus (GDM), which is a strong risk factor for this adverse outcome. There are no prospective studies on this topic in Malaysia. This study aimed to examine prospectively the effects of obesity in pregnancy and GWG, independent of GDM, on neonatal outcome. Methods Pregnant mothers in the first trimester, who presented to health clinics in Kuching, were screened. Mothers with existing diabetes mellitus or GDM were excluded using 75‐g oral glucose tolerance test during the first and second trimesters. Participants with the first trimester BMI ≥ 23 kg/m2 were recruited as overweight/obese group, whereas those with BMI 18.5–22.9 kg/m2 were taken as the comparison group. At every trimester visit, mothers' weights were recorded. Babies' birth weight and occurrence of adverse neonatal outcome were documented. Results There were 123 mothers recruited as overweight/obese group (mean BMI 29.0 kg/m2 ± 4.45) and 102 mothers as comparison group (mean BMI 20.4 kg/m2 ± 1.48). The number of low birth weight was similar between groups: 9.8% in overweight/obese group, 6.9% in the comparison group (p = 0.416). More than half of these babies were born to mothers with inadequate GWG (58.3% in obese group vs. 57.1% in control group, p = 0.077). There was no significant difference in the mean birth weight (3000 g ± 454.5 vs. 3038 g ± 340.8, p = 0.471), preterm delivery (8.13% vs. 3.92%, p = 0.193), and admission rate to neonatal intensive care unit (8.13% vs. 7.85%, p = 0.937) between groups. There was a positive correlation between the total GWG in overweight/obese group on baby's weight (r = 0.222, p = 0.013). Inadequate GWG was not correlated with lower birth weight (p = 0.052). Conclusions Obesity in pregnancy was not associated with poor neonatal outcome in this small sample of women in Malaysia. Total GWG showed a weak correlation with baby's birth weight in overweight/obese group.
topic gestational weight gain
glucose‐tolerant
neonatal outcome
obesity
pregnancy
url https://doi.org/10.1002/osp4.512
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