Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.
Parkinson's disease (PD) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (DA) neurons that leads to motor symptoms. The etiology and pathogenesis of PD are not clear. We found that expression of COUP-TFII, an orphan nuclear receptor, in DA neurons is upregula...
Main Authors: | Chung-Yang Kao, Mafei Xu, Leiming Wang, Shih-Chieh Lin, Hui-Ju Lee, Lita Duraine, Hugo J Bellen, David S Goldstein, Sophia Y Tsai, Ming-Jer Tsai |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-06-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1008868 |
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