Long-term reversal of diabetes by subcutaneous transplantation of pancreatic islet cells and adipose-derived stem cell sheet using surface-immobilized heparin and engineered collagen scaffold

Long-term reversal of diabetes by subcutaneous transplantation of pancreatic islet cells and adipose-derived stem cell sheet using surface-immobilized heparin and engineered collagen scaffold

Objective Esterified collagen (EC) can be functionalized with heparin to enhance islet graft stability. Growth factors secreted by human adipose-derived stem cells (hADSCs) can bind efficiently to EC-heparin (EC-Hep), which enhances revascularization and cell protection. We investigated the therapeu...

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Bibliographic Details
Main Authors:	Song Cheol Kim, Yang Hee Kim, Jae Hyung Ko, Song Lee, Ju Yun Oh, Gi Seok Jeong, Si-Nae Park, In Kyong Shim
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-04-01
Series:	BMJ Open Diabetes Research & Care
Online Access:	https://drc.bmj.com/content/8/1/e001128.full

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