Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease
Parkinson disease (PD) is a chronic and progressive movement disorder classically characterized by slowed voluntary movements, resting tremor, muscle rigidity, and impaired gait and balance. Medical treatment is highly successful early on, though the majority of people experience significant compli...
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doaj-48dfb52b95f14f41980f2c05ad4d6cd52020-11-24T22:21:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-04-011010.3389/fnins.2016.00173186397Deep brain stimulation: a paradigm shifting approach to treat Parkinson's diseasePatrick eHickey0Mark eStacy1Duke University Medical CenterDuke University Medical CenterParkinson disease (PD) is a chronic and progressive movement disorder classically characterized by slowed voluntary movements, resting tremor, muscle rigidity, and impaired gait and balance. Medical treatment is highly successful early on, though the majority of people experience significant complications in later stages. In advanced PD, when medications no longer adequately control motor symptoms, deep brain stimulation (DBS) offers a powerful therapeutic alternative. DBS involves the surgical implantation of one or more electrodes into specific areas of the brain, which modulate or disrupt abnormal patterns of neural signaling within the targeted region. Outcomes are often dramatic following DBS, with improvements in motor function and reductions motor complications having been repeatedly demonstrated. Given such robust responses, emerging indications for DBS are being investigated. In parallel with expansions of therapeutic scope, advancements within the areas of neurosurgical technique and the precision of stimulation delivery have recently broadened as well. This review focuses on the revolutionary addition of DBS to the therapeutic armamentarium for PD, and summarizes the technological advancements in the areas of neuroimaging and biomedical engineering intended to improve targeting, programming and overall management.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00173/fullDeep Brain StimulationGlobus PallidusSubthalamic NucleusParkinson's diseasepedunculopontine nucleus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrick eHickey Mark eStacy |
spellingShingle |
Patrick eHickey Mark eStacy Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease Frontiers in Neuroscience Deep Brain Stimulation Globus Pallidus Subthalamic Nucleus Parkinson's disease pedunculopontine nucleus |
author_facet |
Patrick eHickey Mark eStacy |
author_sort |
Patrick eHickey |
title |
Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease |
title_short |
Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease |
title_full |
Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease |
title_fullStr |
Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease |
title_full_unstemmed |
Deep brain stimulation: a paradigm shifting approach to treat Parkinson's disease |
title_sort |
deep brain stimulation: a paradigm shifting approach to treat parkinson's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2016-04-01 |
description |
Parkinson disease (PD) is a chronic and progressive movement disorder classically characterized by slowed voluntary movements, resting tremor, muscle rigidity, and impaired gait and balance. Medical treatment is highly successful early on, though the majority of people experience significant complications in later stages. In advanced PD, when medications no longer adequately control motor symptoms, deep brain stimulation (DBS) offers a powerful therapeutic alternative. DBS involves the surgical implantation of one or more electrodes into specific areas of the brain, which modulate or disrupt abnormal patterns of neural signaling within the targeted region. Outcomes are often dramatic following DBS, with improvements in motor function and reductions motor complications having been repeatedly demonstrated. Given such robust responses, emerging indications for DBS are being investigated. In parallel with expansions of therapeutic scope, advancements within the areas of neurosurgical technique and the precision of stimulation delivery have recently broadened as well. This review focuses on the revolutionary addition of DBS to the therapeutic armamentarium for PD, and summarizes the technological advancements in the areas of neuroimaging and biomedical engineering intended to improve targeting, programming and overall management. |
topic |
Deep Brain Stimulation Globus Pallidus Subthalamic Nucleus Parkinson's disease pedunculopontine nucleus |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00173/full |
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