GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice

GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice

ObjectiveGlutamate transporter-1 (GLT-1) and system xc– mediate glutamate uptake and release, respectively. Ceftriaxone has been reported to upregulate GLT-1 expression and improve cognitive decline in APP/PS1 mice. The aim of the present study was to elucidate the role of GLT-1 in ceftriaxone-media...

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Bibliographic Details
Main Authors: JunXia Gao, LiZhe Liu, Chao Liu, ShuJuan Fan, LiRong Liu, ShuFeng Liu, Xiao-Hui Xian, Wen-Bin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
ceftriaxone
GLT-1
GLT-1 knockdown
glutamate uptake
xCT
glutathione level
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.580772/full

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