Coordination of endothelial cell positioning and fate specification by the epicardium

It remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to coronary vessel patterning and maturation in the ep...

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Main Authors:	Pearl Quijada, Michael A. Trembley, Adwiteeya Misra, Jacquelyn A. Myers, Cameron D. Baker, Marta Pérez-Hernández, Jason R. Myers, Ronald A. Dirkx, Ethan David Cohen, Mario Delmar, John M. Ashton, Eric M. Small
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24414-z

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spelling	doaj-490625a4402947fb92af5dfa148615952021-07-11T11:42:54ZengNature Publishing GroupNature Communications2041-17232021-07-0112111810.1038/s41467-021-24414-zCoordination of endothelial cell positioning and fate specification by the epicardiumPearl Quijada0Michael A. Trembley1Adwiteeya Misra2Jacquelyn A. Myers3Cameron D. Baker4Marta Pérez-Hernández5Jason R. Myers6Ronald A. Dirkx7Ethan David Cohen8Mario Delmar9John M. Ashton10Eric M. Small11Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and DentistryDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and DentistryDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and DentistryGenomics Research Center, University of Rochester School of Medicine and DentistryGenomics Research Center, University of Rochester School of Medicine and DentistryLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of MedicineGenomics Research Center, University of Rochester School of Medicine and DentistryDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and DentistryDepartment of Pediatrics, University of Rochester School of Medicine and DentistryLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of MedicineGenomics Research Center, University of Rochester School of Medicine and DentistryDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and DentistryIt remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to coronary vessel patterning and maturation in the epicardium.https://doi.org/10.1038/s41467-021-24414-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pearl Quijada Michael A. Trembley Adwiteeya Misra Jacquelyn A. Myers Cameron D. Baker Marta Pérez-Hernández Jason R. Myers Ronald A. Dirkx Ethan David Cohen Mario Delmar John M. Ashton Eric M. Small
spellingShingle	Pearl Quijada Michael A. Trembley Adwiteeya Misra Jacquelyn A. Myers Cameron D. Baker Marta Pérez-Hernández Jason R. Myers Ronald A. Dirkx Ethan David Cohen Mario Delmar John M. Ashton Eric M. Small Coordination of endothelial cell positioning and fate specification by the epicardium Nature Communications
author_facet	Pearl Quijada Michael A. Trembley Adwiteeya Misra Jacquelyn A. Myers Cameron D. Baker Marta Pérez-Hernández Jason R. Myers Ronald A. Dirkx Ethan David Cohen Mario Delmar John M. Ashton Eric M. Small
author_sort	Pearl Quijada
title	Coordination of endothelial cell positioning and fate specification by the epicardium
title_short	Coordination of endothelial cell positioning and fate specification by the epicardium
title_full	Coordination of endothelial cell positioning and fate specification by the epicardium
title_fullStr	Coordination of endothelial cell positioning and fate specification by the epicardium
title_full_unstemmed	Coordination of endothelial cell positioning and fate specification by the epicardium
title_sort	coordination of endothelial cell positioning and fate specification by the epicardium
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	It remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to coronary vessel patterning and maturation in the epicardium.
url	https://doi.org/10.1038/s41467-021-24414-z
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Coordination of endothelial cell positioning and fate specification by the epicardium

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