Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease
Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington’s disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual slee...
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Elsevier
2019-01-01
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Series: | Neurobiology of Sleep and Circadian Rhythms |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994418300075 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Danielle M. Bartlett Juan F. Domínguez D Alvaro Reyes Pauline Zaenker Kirk W. Feindel Robert U. Newton Anthony J. Hannan James A. Slater Peter R. Eastwood Alpar S. Lazar Mel Ziman Travis Cruickshank |
spellingShingle |
Danielle M. Bartlett Juan F. Domínguez D Alvaro Reyes Pauline Zaenker Kirk W. Feindel Robert U. Newton Anthony J. Hannan James A. Slater Peter R. Eastwood Alpar S. Lazar Mel Ziman Travis Cruickshank Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease Neurobiology of Sleep and Circadian Rhythms |
author_facet |
Danielle M. Bartlett Juan F. Domínguez D Alvaro Reyes Pauline Zaenker Kirk W. Feindel Robert U. Newton Anthony J. Hannan James A. Slater Peter R. Eastwood Alpar S. Lazar Mel Ziman Travis Cruickshank |
author_sort |
Danielle M. Bartlett |
title |
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease |
title_short |
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease |
title_full |
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease |
title_fullStr |
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease |
title_full_unstemmed |
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease |
title_sort |
investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest huntington's disease |
publisher |
Elsevier |
series |
Neurobiology of Sleep and Circadian Rhythms |
issn |
2451-9944 |
publishDate |
2019-01-01 |
description |
Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington’s disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens. Keywords: Huntington’s disease, Hypothalamus, Magnetic resonance imaging, Circadian rhythm, Sleep |
url |
http://www.sciencedirect.com/science/article/pii/S2451994418300075 |
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doaj-490848a46f9d49a79cfe9feb07611c3e2020-11-25T00:50:21ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442019-01-01618Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's diseaseDanielle M. Bartlett0Juan F. Domínguez D1Alvaro Reyes2Pauline Zaenker3Kirk W. Feindel4Robert U. Newton5Anthony J. Hannan6James A. Slater7Peter R. Eastwood8Alpar S. Lazar9Mel Ziman10Travis Cruickshank11School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia; Corresponding author.School of Psychology, Australian Catholic University, Melbourne, Victoria, AustraliaFacultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, ChileSchool of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, AustraliaCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, Western Australia, AustraliaExercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, AustraliaThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, AustraliaCentre for Sleep Science, School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, Western Australia, AustraliaCentre for Sleep Science, School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, Western Australia, AustraliaFaculty of Medicine and Health Sciences, University of East Anglia, Norwich, Norfolk, United KingdomSchool of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia; School of Biomedical Science, University of Western Australia, Crawley, Western Australia, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia; Peron Institute for Neurological and Translational Science, Perth, Western Australia, AustraliaObjective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington’s disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens. Keywords: Huntington’s disease, Hypothalamus, Magnetic resonance imaging, Circadian rhythm, Sleephttp://www.sciencedirect.com/science/article/pii/S2451994418300075 |