A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia
Abstract Introduction Patients affected by the behavioral variant frontotemporal dementia (bvFTD) frequently experience, at a delayed onset, abnormal eating behavior involving increased food intake. Although delusional food‐related symptoms have attracted much attention, the behavioral and neural fe...
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doaj-4912d6cb0bc24b96a076fc3420e3ab132020-11-25T03:24:24ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110175075410.1016/j.dadm.2018.10.001A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementiaGerardo Salvato0Matteo Mercurio1Maurizio Sberna2Eraldo Paulesu3Gabriella Bottini4Department of Brain and Behavioral SciencesUniversity of PaviaPaviaItalyNeurodegenerative Disease Unit, Department of Pathophysiology and Transplantation, Centro Dino FerrariUniversity of Milan, Fondazione Ca' Granda IRCCS Ospedale Maggiore PoliclinicoMilanItalyDepartment of NeuroradiologyASST Grande Ospedale Metropolitano NiguardaMilanoItalyDepartment of PsychologyUniversity of Milano‐BicoccaMilanoItalyDepartment of Brain and Behavioral SciencesUniversity of PaviaPaviaItalyAbstract Introduction Patients affected by the behavioral variant frontotemporal dementia (bvFTD) frequently experience, at a delayed onset, abnormal eating behavior involving increased food intake. Although delusional food‐related symptoms have attracted much attention, the behavioral and neural features of food aversion manifestations in bvFTD remain poorly documented. Methods We describe the rare case of a patient with bvFTD presenting with lack of interoception for swallowing and digestion, coupled with a dramatic food aversion at onset. We also compared his MRI scan to 84 healthy individuals using a voxel‐based morphometry approach. Results We found gray matter density reductions involving the postcentral gyrus bilaterally, insulae, and right medial orbitofrontal cortex. Discussion Our results shed new light on the behavioral and neuroanatomical features of food aversion and interoception deficits in bvFTD, suggesting that besides orbitofrontal cortex, also a distributed system associated with interoception might play a role in such behavioral manifestation.https://doi.org/10.1016/j.dadm.2018.10.001Behavioral variant frontotemporal dementiaInteroceptionEating disturbancesInsulaVoxel‐based morphometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gerardo Salvato Matteo Mercurio Maurizio Sberna Eraldo Paulesu Gabriella Bottini |
spellingShingle |
Gerardo Salvato Matteo Mercurio Maurizio Sberna Eraldo Paulesu Gabriella Bottini A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Behavioral variant frontotemporal dementia Interoception Eating disturbances Insula Voxel‐based morphometry |
author_facet |
Gerardo Salvato Matteo Mercurio Maurizio Sberna Eraldo Paulesu Gabriella Bottini |
author_sort |
Gerardo Salvato |
title |
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
title_short |
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
title_full |
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
title_fullStr |
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
title_full_unstemmed |
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
title_sort |
very light lunch: interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2018-01-01 |
description |
Abstract Introduction Patients affected by the behavioral variant frontotemporal dementia (bvFTD) frequently experience, at a delayed onset, abnormal eating behavior involving increased food intake. Although delusional food‐related symptoms have attracted much attention, the behavioral and neural features of food aversion manifestations in bvFTD remain poorly documented. Methods We describe the rare case of a patient with bvFTD presenting with lack of interoception for swallowing and digestion, coupled with a dramatic food aversion at onset. We also compared his MRI scan to 84 healthy individuals using a voxel‐based morphometry approach. Results We found gray matter density reductions involving the postcentral gyrus bilaterally, insulae, and right medial orbitofrontal cortex. Discussion Our results shed new light on the behavioral and neuroanatomical features of food aversion and interoception deficits in bvFTD, suggesting that besides orbitofrontal cortex, also a distributed system associated with interoception might play a role in such behavioral manifestation. |
topic |
Behavioral variant frontotemporal dementia Interoception Eating disturbances Insula Voxel‐based morphometry |
url |
https://doi.org/10.1016/j.dadm.2018.10.001 |
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