Clinical efficacy and safety studies on dry eye patients treated with artificial tears and non-steroidal anti-inflammatory drug

• Main Author: Guo-Ying Zhang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2015-11-01
• Series: Guoji Yanke Zazhi
• Subjects: artificial tears; non-steroidal anti-inflammatory drug; dry eye; clinical effect
• Online Access: http://ies.ijo.cn/cn_publish/2015/11/201511031.pdf

AIM:To investigate clinical efficacy and safety of artivicial tears combined with non-steroidal anti-inflammatory drugs(NSAID)on treating dry eyes in order to improve the level of clinical diagnosis and treatments. <p>METHODS:One hundred and two patients with dry eyes from July 2012 to July 2014 were selected, and they were divided into observation group(51 patients)and control group(51 patients). Patients in control group were treated with NSAID. Patients in observation group were treated with artificial tears and NSAID. Indicators of the two groups were observed before and after treatments. <p>RESULTS: The cure rate and total effective rate of control group were 23.5% and 76.5%, those of observation group were 35.3% and 92.2%. The differences were statistically significant(<i>P</i><0.05)between two groups. The differences of the two groups before and after treatments on BUT, FL, rose Bengal, ISV, IVA, SⅠt were statistically significant(<i>P</i><0.05). Adverse reactions: in control group, the rate of eyelid redness, irritated by foreign body, conjunctival hyperemia or edema, secretions, itching were 13.7%, 7.8%, 11.8%, 5.9%, 5.9% respectively, those of the observation group were 3.9%, 2.0%, 2.0%, 0, 2.0%. The differences between the two groups on those items were statistically significant(<i>P</i><0.05), except on itching. <p>CONCLUSION:The artificial tears combined with NAISD have remarkble effect on the treatment of dry eyes and have lower rate of adverse reaction.