FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE

• Main Authors: Yuwaraj Dilipsingh Dixit, Pravin Babarao Suruse, Umesh Dhaniram Shivhare
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2013-01-01
• Series: Indonesian Journal of Pharmacy
• Subjects: Domperidone maleate; Mucoadhesive tablet; antiemetic
• Online Access: http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/515/393

The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperidone maleate. It is an antiemetic synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Mucoadhesive Domperidone maleate tablet formulation was prepared by direct compression method. The formulation F3 containing (Carbopol 940 + sodium alginate) was found to be best among all the formulation batches because of its consistent release rate for 7 h and extent of drug release was 94.44%. Graphical treatment of the formulation F3 to Higuchi’s equation showed that the drug release was diffusion mediated. In-vitro permeability study for formulation F3 for 7 h had shown 76.69% drug release. FTIR studies showed no evidence on interaction between drug and polymers.