Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water
Frequent heavy-metal pollution accidents severely deteriorated the source water quality of drinking water treatment plants (DWTP). Limited data have explicitly addressed the impact of these incidents on bacterial antibiotic resistance (BAR). In present study, we investigated the shift of antibiotic...
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doaj-4921a20929ca4036b3dc48f7d0ab424c2020-11-25T02:39:52ZengElsevierEnvironment International0160-41202020-02-01135Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source waterMenglu Zhang0Kun Wan1Jie Zeng2Wenfang Lin3Chengsong Ye4Xin Yu5College of Environmental Science and Engineering, Fujian Normal University, Fuzhou 350007, China; Key Laboratory of Resource Cycle and Pollution Control of Fujian Province, Fujian Normal University, Fuzhou 350007, ChinaKey Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Science, Beijing 100049, ChinaKey Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Science, Beijing 100049, ChinaKey Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, ChinaCollege of the Environment and Ecology, Xiamen University, Xiamen 361102, ChinaKey Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; College of the Environment and Ecology, Xiamen University, Xiamen 361102, China; Corresponding author at: Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. College of the Environment and Ecology, Xiamen University, Xiamen 361102, China.Frequent heavy-metal pollution accidents severely deteriorated the source water quality of drinking water treatment plants (DWTP). Limited data have explicitly addressed the impact of these incidents on bacterial antibiotic resistance (BAR). In present study, we investigated the shift of antibiotic resistome caused by heavy metal pollution incidents via simulating an arsenic shock loading [As (III)], along with the associated risks imposed on drinking water systems. The results indicated that a quick co-selection of antibiotic resistant bacteria (ARB) was achieved after exposure to 0.2–1 mg/L As (III) for only 6 h, meanwhile, there was an increase of relative abundance of antibiotic resistance genes (ARGs) and mobile genetic elements. Most of the co-selected BAR could be maintained for at least 4 days in the absence of As (III) and antibiotics, implying that the pollution in source water possibly contributed to the preservation and proliferation of antibiotic resistance determinants in the subsequent DWTP. Bacterial community structure analysis showed a strong correlation between bacterial community shift and BAR promotion, and enrichment of opportunistic bacteria (e.g. Escherichia-Shigella, Empedobacter sp. and Elizabethkingia sp.). The results indicated a potential epidemiological threat to the public due to accident-level arsenic contamination in the source water. This study gave insight into understanding the source water pollution accidents from the perspective of bio-hazard and biological risks, and highlighted a neglected important source of BAR in drinking water systems. Keywords: Accidental arsenic pollution, Co-selection, Bacterial antibiotic resistance, Antibiotic resistance genes, Drinking waterhttp://www.sciencedirect.com/science/article/pii/S0160412019328636 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Menglu Zhang Kun Wan Jie Zeng Wenfang Lin Chengsong Ye Xin Yu |
spellingShingle |
Menglu Zhang Kun Wan Jie Zeng Wenfang Lin Chengsong Ye Xin Yu Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water Environment International |
author_facet |
Menglu Zhang Kun Wan Jie Zeng Wenfang Lin Chengsong Ye Xin Yu |
author_sort |
Menglu Zhang |
title |
Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
title_short |
Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
title_full |
Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
title_fullStr |
Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
title_full_unstemmed |
Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
title_sort |
co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2020-02-01 |
description |
Frequent heavy-metal pollution accidents severely deteriorated the source water quality of drinking water treatment plants (DWTP). Limited data have explicitly addressed the impact of these incidents on bacterial antibiotic resistance (BAR). In present study, we investigated the shift of antibiotic resistome caused by heavy metal pollution incidents via simulating an arsenic shock loading [As (III)], along with the associated risks imposed on drinking water systems. The results indicated that a quick co-selection of antibiotic resistant bacteria (ARB) was achieved after exposure to 0.2–1 mg/L As (III) for only 6 h, meanwhile, there was an increase of relative abundance of antibiotic resistance genes (ARGs) and mobile genetic elements. Most of the co-selected BAR could be maintained for at least 4 days in the absence of As (III) and antibiotics, implying that the pollution in source water possibly contributed to the preservation and proliferation of antibiotic resistance determinants in the subsequent DWTP. Bacterial community structure analysis showed a strong correlation between bacterial community shift and BAR promotion, and enrichment of opportunistic bacteria (e.g. Escherichia-Shigella, Empedobacter sp. and Elizabethkingia sp.). The results indicated a potential epidemiological threat to the public due to accident-level arsenic contamination in the source water. This study gave insight into understanding the source water pollution accidents from the perspective of bio-hazard and biological risks, and highlighted a neglected important source of BAR in drinking water systems. Keywords: Accidental arsenic pollution, Co-selection, Bacterial antibiotic resistance, Antibiotic resistance genes, Drinking water |
url |
http://www.sciencedirect.com/science/article/pii/S0160412019328636 |
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