Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa
This case series documents local experience using accelerated theta-burst repetitive transcranial magnetic stimulation (rTMS) as a supplementary treatment for depression in both major depressive disorder (MDD) and bipolar disorder (BD). Nine consenting patients (MDD = 7; BD = 2) each received 20 acc...
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doaj-4923b496973d4704bad3627e49fbb9472020-11-25T01:37:15ZengAOSISSouth African Journal of Psychiatry 1608-96852078-67862019-11-01250e1e410.4102/sajpsychiatry.v25i0.1346476Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South AfricaErine Bröcker0Leigh van den Heuvel1Soraya Seedat2Department of Psychiatry, Faculty of Medical Health Sciences, Stellenbosch University, Cape TownDepartment of Psychiatry, Faculty of Medical Health Sciences, Stellenbosch University, Cape TownDepartment of Psychiatry, Faculty of Medical Health Sciences, Stellenbosch University, Cape TownThis case series documents local experience using accelerated theta-burst repetitive transcranial magnetic stimulation (rTMS) as a supplementary treatment for depression in both major depressive disorder (MDD) and bipolar disorder (BD). Nine consenting patients (MDD = 7; BD = 2) each received 20 accelerated theta-burst sessions over 8 days. Improvement was monitored using the Centre for Epidemiological Studies Depression (CES-D) Scale and the Clinical Global Impression (CGI) Scale at baseline, at day 5 and at day 8 of rTMS treatment. We performed a Wilcoxon matched-pairs signed-rank test to determine whether there was a difference in scores from baseline to post-treatment. The CES-D scores decreased significantly from baseline to post-treatment (Z = −2.547, p = 0.011) with five patients experiencing at least a 50% symptom reduction on the CES-D. CGI severity scores also decreased significantly between baseline and post-treatment (Z = −2.547, p = 0.011). The most commonly reported adverse effect was mild headaches, lasting a few hours during and after rTMS treatment. The findings suggest that the accelerated theta-burst rTMS protocol for depression is well tolerated with most patients also experiencing symptomatic improvement by day 8.https://sajp.org.za/index.php/sajp/article/view/1346theta-burst stimulationtbsdepressionaccelerated repetitive transcranial magnetic stimulationbipolar depressionbptreatment resistant depression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Erine Bröcker Leigh van den Heuvel Soraya Seedat |
spellingShingle |
Erine Bröcker Leigh van den Heuvel Soraya Seedat Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa South African Journal of Psychiatry theta-burst stimulation tbs depression accelerated repetitive transcranial magnetic stimulation bipolar depression bp treatment resistant depression |
author_facet |
Erine Bröcker Leigh van den Heuvel Soraya Seedat |
author_sort |
Erine Bröcker |
title |
Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa |
title_short |
Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa |
title_full |
Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa |
title_fullStr |
Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa |
title_full_unstemmed |
Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa |
title_sort |
accelerated theta-burst repetitive transcranial magnetic stimulation for depression in south africa |
publisher |
AOSIS |
series |
South African Journal of Psychiatry |
issn |
1608-9685 2078-6786 |
publishDate |
2019-11-01 |
description |
This case series documents local experience using accelerated theta-burst repetitive transcranial magnetic stimulation (rTMS) as a supplementary treatment for depression in both major depressive disorder (MDD) and bipolar disorder (BD). Nine consenting patients (MDD = 7; BD = 2) each received 20 accelerated theta-burst sessions over 8 days. Improvement was monitored using the Centre for Epidemiological Studies Depression (CES-D) Scale and the Clinical Global Impression (CGI) Scale at baseline, at day 5 and at day 8 of rTMS treatment. We performed a Wilcoxon matched-pairs signed-rank test to determine whether there was a difference in scores from baseline to post-treatment. The CES-D scores decreased significantly from baseline to post-treatment (Z = −2.547, p = 0.011) with five patients experiencing at least a 50% symptom reduction on the CES-D. CGI severity scores also decreased significantly between baseline and post-treatment (Z = −2.547, p = 0.011). The most commonly reported adverse effect was mild headaches, lasting a few hours during and after rTMS treatment. The findings suggest that the accelerated theta-burst rTMS protocol for depression is well tolerated with most patients also experiencing symptomatic improvement by day 8. |
topic |
theta-burst stimulation tbs depression accelerated repetitive transcranial magnetic stimulation bipolar depression bp treatment resistant depression |
url |
https://sajp.org.za/index.php/sajp/article/view/1346 |
work_keys_str_mv |
AT erinebrocker acceleratedthetaburstrepetitivetranscranialmagneticstimulationfordepressioninsouthafrica AT leighvandenheuvel acceleratedthetaburstrepetitivetranscranialmagneticstimulationfordepressioninsouthafrica AT sorayaseedat acceleratedthetaburstrepetitivetranscranialmagneticstimulationfordepressioninsouthafrica |
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1725058828644384768 |