Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs.
While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study i...
Main Authors: | Pernille Tveden-Nyborg, Lucile Vogt, Janne G Schjoldager, Natalie Jeannet, Stine Hasselholt, Maya D Paidi, Stephan Christen, Jens Lykkesfeldt |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23119033/?tool=EBI |
Similar Items
-
Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains
by: Maya D. Paidi, et al.
Published: (2014-01-01) -
Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression
by: Maya D. Paidi, et al.
Published: (2014-04-01) -
Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model
by: Stine N. Hansen, et al.
Published: (2018-06-01) -
l-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs
by: Henriette Frikke-Schmidt, et al.
Published: (2016-04-01) -
The Pharmacokinetics of Vitamin C
by: Jens Lykkesfeldt, et al.
Published: (2019-10-01)