Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited....
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doaj-4927093b4535493f822eea68f41d2e982021-03-18T04:34:47ZengElsevierBrain Stimulation1935-861X2010-04-01326577Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictionsAshutosh Chaturvedi0Christopher R. Butson1Scott F. Lempka2Scott E. Cooper3Cameron C. McIntyre4Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USADepartment of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USACenter for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, OH, USADepartment of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Center for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, OH, USA; Correspondence: Cameron C. McIntyre, Cleveland Clinic Foundation, Department of Biomedical Engineering, 9500 Euclid Avenue ND-20, Cleveland, Ohio 44195, Telephone: (216) 445-3264, Fax: (216) 444-9198.Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational models of varying levels of complexity have been used to study the neural response to DBS. The goal of this study was to evaluate the quantitative impact of incrementally incorporating increasing levels of complexity into computer models of STN DBS. Our analysis focused on the direct activation of experimentally measureable fiber pathways within the internal capsule (IC). Our model system was customized to an STN DBS patient and stimulation thresholds for activation of IC axons were calculated with electric field models that ranged from an electrostatic, homogenous, isotropic model to one that explicitly incorporated the voltage-drop and capacitance of the electrode-electrolyte interface, tissue encapsulation of the electrode, and diffusion-tensor based 3D tissue anisotropy and inhomogeneity. The model predictions were compared to experimental IC activation defined from electromyographic (EMG) recordings from eight different muscle groups in the contralateral arm and leg of the STN DBS patient. Coupled evaluation of the model and experimental data showed that the most realistic predictions of axonal thresholds were achieved with the most detailed model. Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation.http://www.sciencedirect.com/science/article/pii/S1935861X10000136deep brain stimulationcomputational modelingneural activationParkinson's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashutosh Chaturvedi Christopher R. Butson Scott F. Lempka Scott E. Cooper Cameron C. McIntyre |
spellingShingle |
Ashutosh Chaturvedi Christopher R. Butson Scott F. Lempka Scott E. Cooper Cameron C. McIntyre Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions Brain Stimulation deep brain stimulation computational modeling neural activation Parkinson's disease |
author_facet |
Ashutosh Chaturvedi Christopher R. Butson Scott F. Lempka Scott E. Cooper Cameron C. McIntyre |
author_sort |
Ashutosh Chaturvedi |
title |
Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions |
title_short |
Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions |
title_full |
Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions |
title_fullStr |
Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions |
title_full_unstemmed |
Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions |
title_sort |
patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictions |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2010-04-01 |
description |
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational models of varying levels of complexity have been used to study the neural response to DBS. The goal of this study was to evaluate the quantitative impact of incrementally incorporating increasing levels of complexity into computer models of STN DBS. Our analysis focused on the direct activation of experimentally measureable fiber pathways within the internal capsule (IC). Our model system was customized to an STN DBS patient and stimulation thresholds for activation of IC axons were calculated with electric field models that ranged from an electrostatic, homogenous, isotropic model to one that explicitly incorporated the voltage-drop and capacitance of the electrode-electrolyte interface, tissue encapsulation of the electrode, and diffusion-tensor based 3D tissue anisotropy and inhomogeneity. The model predictions were compared to experimental IC activation defined from electromyographic (EMG) recordings from eight different muscle groups in the contralateral arm and leg of the STN DBS patient. Coupled evaluation of the model and experimental data showed that the most realistic predictions of axonal thresholds were achieved with the most detailed model. Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation. |
topic |
deep brain stimulation computational modeling neural activation Parkinson's disease |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X10000136 |
work_keys_str_mv |
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