Targeting hypoxic tumor microenvironment in pancreatic cancer

Targeting hypoxic tumor microenvironment in pancreatic cancer

Abstract Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic cancer harbors ample stromal cells and abundant extracellular matrix but lacks vascularization, resulting in p...

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Bibliographic Details
Main Authors: Jinxin Tao, Gang Yang, Wenchuan Zhou, Jiangdong Qiu, Guangyu Chen, Wenhao Luo, Fangyu Zhao, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Hematology & Oncology
Subjects:
Hypoxia
Metabolic reprogramming
Redox homeostasis
Autophagy
Stemness
EMT and metastasis
Online Access:https://doi.org/10.1186/s13045-020-01030-w

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