Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex
A novel eight-coordinated dinuclear Ca(II) complex, [Ca2(L)2(H2O)10]·H2O (L = 4-formylbenzene-1,3-disulfonate-3-pyridinecarboxylic hydrazone) (1), was synthesized by the reaction of 3-pyridinecarboxylic hydrazide, disodium 4-formylbenzene-1,3-disulfonate, and Ca(ClO4)2·4H2O in ethanol-water solution...
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doaj-492d2d2c9eed49adae29c7352ce7dc8c2020-11-24T22:26:35ZengMDPI AGCrystals2073-43522016-09-016910910.3390/cryst6090109cryst6090109Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base ComplexXi-Shi Tai0Qing-Guo Meng1Li-Li Liu2College of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, ChinaCollege of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, ChinaCollege of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, ChinaA novel eight-coordinated dinuclear Ca(II) complex, [Ca2(L)2(H2O)10]·H2O (L = 4-formylbenzene-1,3-disulfonate-3-pyridinecarboxylic hydrazone) (1), was synthesized by the reaction of 3-pyridinecarboxylic hydrazide, disodium 4-formylbenzene-1,3-disulfonate, and Ca(ClO4)2·4H2O in ethanol-water solution (v:v = 3:1) at 50 °C. Complex 1 was characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and X-ray single crystal diffraction analysis. Dinuclear Ca(II) complex 1 belongs to triclinic, space group P-1 with a = 7.186(3) Å, b = 11.978(5) Å, c = 12.263(5) Å, α = 90.318(5)°, β = 91.922(5)°, γ = 96.797(5)°, V = 1047.5(8) Å3, Z = 1, Dc = 1.685 mg·m−3, μ = 0.572 mm−1, F(000) = 552, and final R1 = 0.0308, ωR2 = 0.0770. Dinuclear Ca(II) molecules form a 1D chained structure by π–π stacking interaction. The 1D chains form a 3D framework structure by the π–π stacking interaction and hydrogen bonds. The in vitro cytotoxic activity activity of 1 against HL-60 and MLTC-1 was also investigated.http://www.mdpi.com/2073-4352/6/9/1093-Pyridinecarboxylic hydrazidedisodium 4-formylbenzene-1,3-disulfonatedinuclear Ca(II) complexsynthesiscrystal structurein vitro cytotoxic activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xi-Shi Tai Qing-Guo Meng Li-Li Liu |
spellingShingle |
Xi-Shi Tai Qing-Guo Meng Li-Li Liu Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex Crystals 3-Pyridinecarboxylic hydrazide disodium 4-formylbenzene-1,3-disulfonate dinuclear Ca(II) complex synthesis crystal structure in vitro cytotoxic activity |
author_facet |
Xi-Shi Tai Qing-Guo Meng Li-Li Liu |
author_sort |
Xi-Shi Tai |
title |
Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex |
title_short |
Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex |
title_full |
Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex |
title_fullStr |
Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex |
title_full_unstemmed |
Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex |
title_sort |
synthesis, crystal structure, and cytotoxic activity of a novel eight-coordinated dinuclear ca(ii)-schiff base complex |
publisher |
MDPI AG |
series |
Crystals |
issn |
2073-4352 |
publishDate |
2016-09-01 |
description |
A novel eight-coordinated dinuclear Ca(II) complex, [Ca2(L)2(H2O)10]·H2O (L = 4-formylbenzene-1,3-disulfonate-3-pyridinecarboxylic hydrazone) (1), was synthesized by the reaction of 3-pyridinecarboxylic hydrazide, disodium 4-formylbenzene-1,3-disulfonate, and Ca(ClO4)2·4H2O in ethanol-water solution (v:v = 3:1) at 50 °C. Complex 1 was characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and X-ray single crystal diffraction analysis. Dinuclear Ca(II) complex 1 belongs to triclinic, space group P-1 with a = 7.186(3) Å, b = 11.978(5) Å, c = 12.263(5) Å, α = 90.318(5)°, β = 91.922(5)°, γ = 96.797(5)°, V = 1047.5(8) Å3, Z = 1, Dc = 1.685 mg·m−3, μ = 0.572 mm−1, F(000) = 552, and final R1 = 0.0308, ωR2 = 0.0770. Dinuclear Ca(II) molecules form a 1D chained structure by π–π stacking interaction. The 1D chains form a 3D framework structure by the π–π stacking interaction and hydrogen bonds. The in vitro cytotoxic activity activity of 1 against HL-60 and MLTC-1 was also investigated. |
topic |
3-Pyridinecarboxylic hydrazide disodium 4-formylbenzene-1,3-disulfonate dinuclear Ca(II) complex synthesis crystal structure in vitro cytotoxic activity |
url |
http://www.mdpi.com/2073-4352/6/9/109 |
work_keys_str_mv |
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1725752806378307584 |