Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord
Propriospinal interneurons (INs) communicate information over short and long distances within the spinal cord. They act to coordinate different parts of the body by linking motor circuits that control muscles across the forelimbs, trunk, and hindlimbs. Their role in coordinating locomotor circuits n...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-11-01
|
Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00512/full |
id |
doaj-493b1d24ab634ae0b853b8f1a4a670df |
---|---|
record_format |
Article |
spelling |
doaj-493b1d24ab634ae0b853b8f1a4a670df2020-11-24T21:11:03ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-11-011310.3389/fncel.2019.00512494495Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal CordAlex M. LaliberteSara GoltashNicolas R. LalondeTuan Vu BuiPropriospinal interneurons (INs) communicate information over short and long distances within the spinal cord. They act to coordinate different parts of the body by linking motor circuits that control muscles across the forelimbs, trunk, and hindlimbs. Their role in coordinating locomotor circuits near and far may be invaluable to the recovery of locomotor function lost due to injury to the spinal cord where the flow of motor commands from the brain and brainstem to spinal motor circuits is disrupted. The formation and activation of circuits established by spared propriospinal INs may promote the re-emergence of locomotion. In light of progress made in animal models of spinal cord injury (SCI) and in human patients, we discuss the role of propriospinal INs in the intact spinal cord and describe recent studies investigating the assembly and/or activation of propriospinal circuits to promote recovery of locomotion following SCI.https://www.frontiersin.org/article/10.3389/fncel.2019.00512/fullpropriospinal neuronsspinal locomotor networkscentral pattern generatorsspinal cord injurydetour circuits |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alex M. Laliberte Sara Goltash Nicolas R. Lalonde Tuan Vu Bui |
spellingShingle |
Alex M. Laliberte Sara Goltash Nicolas R. Lalonde Tuan Vu Bui Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord Frontiers in Cellular Neuroscience propriospinal neurons spinal locomotor networks central pattern generators spinal cord injury detour circuits |
author_facet |
Alex M. Laliberte Sara Goltash Nicolas R. Lalonde Tuan Vu Bui |
author_sort |
Alex M. Laliberte |
title |
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord |
title_short |
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord |
title_full |
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord |
title_fullStr |
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord |
title_full_unstemmed |
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord |
title_sort |
propriospinal neurons: essential elements of locomotor control in the intact and possibly the injured spinal cord |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2019-11-01 |
description |
Propriospinal interneurons (INs) communicate information over short and long distances within the spinal cord. They act to coordinate different parts of the body by linking motor circuits that control muscles across the forelimbs, trunk, and hindlimbs. Their role in coordinating locomotor circuits near and far may be invaluable to the recovery of locomotor function lost due to injury to the spinal cord where the flow of motor commands from the brain and brainstem to spinal motor circuits is disrupted. The formation and activation of circuits established by spared propriospinal INs may promote the re-emergence of locomotion. In light of progress made in animal models of spinal cord injury (SCI) and in human patients, we discuss the role of propriospinal INs in the intact spinal cord and describe recent studies investigating the assembly and/or activation of propriospinal circuits to promote recovery of locomotion following SCI. |
topic |
propriospinal neurons spinal locomotor networks central pattern generators spinal cord injury detour circuits |
url |
https://www.frontiersin.org/article/10.3389/fncel.2019.00512/full |
work_keys_str_mv |
AT alexmlaliberte propriospinalneuronsessentialelementsoflocomotorcontrolintheintactandpossiblytheinjuredspinalcord AT saragoltash propriospinalneuronsessentialelementsoflocomotorcontrolintheintactandpossiblytheinjuredspinalcord AT nicolasrlalonde propriospinalneuronsessentialelementsoflocomotorcontrolintheintactandpossiblytheinjuredspinalcord AT tuanvubui propriospinalneuronsessentialelementsoflocomotorcontrolintheintactandpossiblytheinjuredspinalcord |
_version_ |
1716754683987492864 |