HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma

HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma

Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in car...

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Main Authors: Yanbin Wang, Zhaoqiang Jiang, Jianing Yan, Shibo Ying
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2019/4183157
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spelling doaj-493ec0fac2ba466e9c73e24279d010462020-11-25T00:28:48ZengHindawi LimitedDisease Markers0278-02401875-86302019-01-01201910.1155/2019/41831574183157HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant MesotheliomaYanbin Wang0Zhaoqiang Jiang1Jianing Yan2Shibo Ying3Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaInstitute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaDepartment of General Surgery, Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310016, ChinaInstitute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaMalignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on in vivo and in vitro experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. We conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.http://dx.doi.org/10.1155/2019/4183157
collection DOAJ
language English
format Article
sources DOAJ
author Yanbin Wang
Zhaoqiang Jiang
Jianing Yan
Shibo Ying
spellingShingle Yanbin Wang
Zhaoqiang Jiang
Jianing Yan
Shibo Ying
HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
Disease Markers
author_facet Yanbin Wang
Zhaoqiang Jiang
Jianing Yan
Shibo Ying
author_sort Yanbin Wang
title HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
title_short HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
title_full HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
title_fullStr HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
title_full_unstemmed HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma
title_sort hmgb1 as a potential biomarker and therapeutic target for malignant mesothelioma
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2019-01-01
description Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on in vivo and in vitro experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. We conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.
url http://dx.doi.org/10.1155/2019/4183157
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AT zhaoqiangjiang hmgb1asapotentialbiomarkerandtherapeutictargetformalignantmesothelioma
AT jianingyan hmgb1asapotentialbiomarkerandtherapeutictargetformalignantmesothelioma
AT shiboying hmgb1asapotentialbiomarkerandtherapeutictargetformalignantmesothelioma
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