Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria
Background: The relationship between infertility and hormonal variations has been variously documented, but little has been reported on the interactions between hormonal factors, homocysteine (Hcy), and female infertility. Objective: This study aimed to evaluate the relationship between plasma Hcy l...
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2015-01-01
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doaj-494e37349caa45039c09f71f989c0da12020-11-24T22:01:56ZengWolters Kluwer Medknow PublicationsJournal of Clinical Sciences2468-68592408-74082015-01-01121141910.4103/1595-9587.160761Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, NigeriaVincent Oluseye OsunkaluChristian C MakweOluwatosin Jonadab AkinsolaAdediran AdewumiOluseun Funke AkomolafeBackground: The relationship between infertility and hormonal variations has been variously documented, but little has been reported on the interactions between hormonal factors, homocysteine (Hcy), and female infertility. Objective: This study aimed to evaluate the relationship between plasma Hcy levels and hormonal variations in infertile women. Materials and Methods: This descriptive cross-sectional study was carried out among eligible infertile and fertile women seeking care at the Lagos University Teaching Hospital, Lagos, Nigeria. The subjects were 100 women referred for management of infertility, and the controls were 50 fertile women who had given birth within the past year. Fasting plasma levels of Hcy were estimated using enzyme immunoassay. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, prolactin, and progesterone were measured using Access 2 (Immunoassay systems-beckman coulter, inc.250S.Kraemer blvd.Brea, ca 92821. U.S.A). Results: Mean plasma Hcy levels for subjects and controls were 9.50 ± 1.88 μmol/L and 9.44 ± 1.85 μmol/L, respectively, with no significant variation (P = 0.952). Plasma Hcy was not significantly associated with infertility and hormone levels. The mean serum levels of LH, FSH, and prolactin were significantly higher among subjects compared to controls. Conclusion: Hormonal variations observed in infertile women did not appear to significantly alter plasma Hcy levels, and hyperhomocysteinemia (HHcy) may not have significantly contributed to female infertility in our environment.http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2015;volume=12;issue=1;spage=14;epage=19;aulast=OsunkaluFemalehomocysteinehormone parametersinfertilityNigeria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vincent Oluseye Osunkalu Christian C Makwe Oluwatosin Jonadab Akinsola Adediran Adewumi Oluseun Funke Akomolafe |
spellingShingle |
Vincent Oluseye Osunkalu Christian C Makwe Oluwatosin Jonadab Akinsola Adediran Adewumi Oluseun Funke Akomolafe Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria Journal of Clinical Sciences Female homocysteine hormone parameters infertility Nigeria |
author_facet |
Vincent Oluseye Osunkalu Christian C Makwe Oluwatosin Jonadab Akinsola Adediran Adewumi Oluseun Funke Akomolafe |
author_sort |
Vincent Oluseye Osunkalu |
title |
Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria |
title_short |
Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria |
title_full |
Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria |
title_fullStr |
Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria |
title_full_unstemmed |
Preliminary report on plasma homocysteine and hormonal variations in infertile women in Lagos, Nigeria |
title_sort |
preliminary report on plasma homocysteine and hormonal variations in infertile women in lagos, nigeria |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Clinical Sciences |
issn |
2468-6859 2408-7408 |
publishDate |
2015-01-01 |
description |
Background: The relationship between infertility and hormonal variations has been variously documented, but little has been reported on the interactions between hormonal factors, homocysteine (Hcy), and female infertility. Objective: This study aimed to evaluate the relationship between plasma Hcy levels and hormonal variations in infertile women. Materials and Methods: This descriptive cross-sectional study was carried out among eligible infertile and fertile women seeking care at the Lagos University Teaching Hospital, Lagos, Nigeria. The subjects were 100 women referred for management of infertility, and the controls were 50 fertile women who had given birth within the past year. Fasting plasma levels of Hcy were estimated using enzyme immunoassay. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, prolactin, and progesterone were measured using Access 2 (Immunoassay systems-beckman coulter, inc.250S.Kraemer blvd.Brea, ca 92821. U.S.A). Results: Mean plasma Hcy levels for subjects and controls were 9.50 ± 1.88 μmol/L and 9.44 ± 1.85 μmol/L, respectively, with no significant variation (P = 0.952). Plasma Hcy was not significantly associated with infertility and hormone levels. The mean serum levels of LH, FSH, and prolactin were significantly higher among subjects compared to controls. Conclusion: Hormonal variations observed in infertile women did not appear to significantly alter plasma Hcy levels, and hyperhomocysteinemia (HHcy) may not have significantly contributed to female infertility in our environment. |
topic |
Female homocysteine hormone parameters infertility Nigeria |
url |
http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2015;volume=12;issue=1;spage=14;epage=19;aulast=Osunkalu |
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