<i>NTRK</i> Fusions in Central Nervous System Tumors: A Rare, but Worthy Target

<i>NTRK</i> Fusions in Central Nervous System Tumors: A Rare, but Worthy Target

The neurotrophic tropomyosin receptor kinase (<i>NTRK</i>) genes (<i>NTRK1</i>, <i>NTRK2</i>, and <i>NTRK3</i>) code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors (TRK-A, TRK-B, and TRK-C) which are mainly inv...

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Bibliographic Details
Main Authors: Alessandro Gambella, Rebecca Senetta, Giammarco Collemi, Stefano Gabriele Vallero, Matteo Monticelli, Fabio Cofano, Pietro Zeppa, Diego Garbossa, Alessia Pellerino, Roberta Rudà, Riccardo Soffietti, Franca Fagioli, Mauro Papotti, Paola Cassoni, Luca Bertero
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
central nervous system
glioma
pediatric tumors
molecular pathology
ntrk
gene fusion
targeted therapies
precision medicine
Online Access:https://www.mdpi.com/1422-0067/21/3/753

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